| 脉冲式低剂量率放疗治疗胃癌腹膜后淋巴结转移1例报道并文献复习 |
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| 引用本文： | 刘 君,刘宝瑞,杨 阳. 脉冲式低剂量率放疗治疗胃癌腹膜后淋巴结转移1例报道并文献复习[J]. 现代肿瘤医学, 2018, 0(18): 2897-2900. DOI: 10.3969/j.issn.1672-4992.2018.18.018 |
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| 作者姓名： | 刘 君 刘宝瑞 杨 阳 |
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| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤中心,南京大学临床肿瘤研究所，江苏 南京 210008 |
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| 摘 要： | 目的:本文通过病例报道及文献复习探讨脉冲式低剂量率放疗(pulsed reduced dose-rate radiotherapy,PRDR)治疗胃癌腹膜后淋巴结转移灶的可行性。方法:对1例胃癌术后腹膜后淋巴结转移致腰背部疼痛的病例应用脉冲式低剂量率放射治疗，结合临床资料，随访观察治疗效果并复习国内外相关文献。结果:该患者治疗前腰背部疼痛严重影响生活质量，影像学提示腹膜后巨大淋巴结肿大影。采用脉冲式低剂量率放疗治疗后靶区转移灶体积缩小90%以上，腰背部疼痛消失，复查CT疗效评价达到部分缓解。放疗后无进展生存期（progression-free survival，PFS）达11个月。结论:胃癌腹膜后淋巴结转移灶因解剖位置特殊导致无法耐受常规放疗的毒性，而应用脉冲式低剂量率放疗可以在降低不良反应的同时提高疗效，延长生存期，提高生存质量。因此脉冲式低剂量率放疗可作为胃癌腹膜后淋巴结转移患者的一个治疗选择。
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| 关 键 词： | 胃癌 腹膜后淋巴结转移 脉冲式低剂量率放疗 |
Pulsed reduced dose-rate radiotherapy for retroperitoneal lymph node metastases of gastric carcinoma:One case reportand literature review |
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| Liu Jun,Liu Baorui,Yang Yang. Pulsed reduced dose-rate radiotherapy for retroperitoneal lymph node metastases of gastric carcinoma:One case reportand literature review[J]. Journal of Modern Oncology, 2018, 0(18): 2897-2900. DOI: 10.3969/j.issn.1672-4992.2018.18.018 |
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| Authors: | Liu Jun Liu Baorui Yang Yang |
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| Affiliation: | The Comprehensive Cancer Centre of Drum Tower Hospital,Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University,Jiangsu Nanjing 210008,China. |
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| Abstract: | Objective:To investigate the possibility of the pulsed reduced dose-rate radiotherapy (PRDR) for retroperitoneal lymph node metastases of gastric carcinoma.Methods:Toreview the clinicaldataof1 case of PRDR for retroperitoneal lymph node metastases resulting in lower back pain after operation and analyze the therapeutic effects.Meanwhile,to review the relevant literatures in order to make a deep understanding of PRDR.Results:The patient suffered a serious pain in lower back before PRDR while the CT image suggested a huge retroperitoneal lymph node metastatic lesion.After irradiation the patient's clinical symptoms improved significantly and CT scan showed tumor metastatic lesion shrank dramatically which indicated a significant partial remission (PR).Thepatienthadprogression-free survival (PFS) of 11 months.Conclusion:Due to the anatomical location,normal tissue toxicity of conventional radiotherapy is high for retroperitoneal lymph node metastases of gastric carcinoma,PRDR can reduce the damage to the surrounding tissue while treating the tumor lesion.It can prolong the patients' life and improve their quality of life.Thus,the treatment of PRDR could be a promising therapeutic option for advanced gastric carcinoma with retroperitoneal lymph node metastases. |
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| Keywords: | gastric carcinoma retroperitoneal lymph node metastases pulsed reduced dose-rate radiotherapy |
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