| Bcl-2和Beclin-1在肝癌组织中的表达及其相关性 |
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| 引用本文： | 周 元1,陈 橼1,邵冰峰1,张素青1,张一心1,吴雅珣2,尹必辉3,朱新国4. Bcl-2和Beclin-1在肝癌组织中的表达及其相关性[J]. 现代肿瘤医学, 2018, 0(20): 3263-3267. DOI: 10.3969/j.issn.1672-4992.2018.20.022 |
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| 作者姓名： | 周 元1 陈 橼1 邵冰峰1 张素青1 张一心1 吴雅珣2 尹必辉3 朱新国4 |
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| 作者单位： | 1.南通市肿瘤医院肝胆科；2.病理科，江苏 南通 226300；3.南通大学医学院研究生院，江苏 南通 226001；4.苏州大学第一附属医院普外科，江苏 苏州 215001 |
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| 基金项目： | 南通市卫生局青年科研基金项目（编号:WQ2015044） |
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| 摘 要： | 目的:探讨Bcl-2和Beclin-1在肝癌(hepatocellular carcinoma,HCC)患者术后复发中的作用，并分析肝癌组织中Bcl-2和Beclin-1的蛋白表达是否具有相关性。方法:收集肝癌组织114例，采用免疫组织化学法检测各组中 Bcl-2蛋白和Beclin-1蛋白的表达情况。与患者临床资料进行统计学分析。结果:利用χ2检验发现Bcl-2在HCC中的表达仅与患者的肿瘤个数程度相关，Beclin-1在HCC中的表达仅与患者的肿瘤分化程度相关，差异具有统计学意义。HCC中Bcl-2和Beclin-1蛋白的表达呈负相关（r =-0.61，P＜0.000 1）。Bcl-2表达阳性影响患者的预后(Log-rank=8.892,P=0.002 9)，Beclin-1表达阴性影响患者的预后(Log-rank=5.350,P=0.020 7)。多因素分析显示肿瘤的肝内复发与肝内肿瘤个数、Bcl-2表达有关。结论:Bcl-2和Beclin-1在肝癌中具有相关性，共同影响患者的预后。
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| 关 键 词： | 肝癌 Bcl-2 Beclin-1 凋亡 自噬 |
The expression and correlation of Bcl-2 and Beclin-1 in hepatocellular carcinoma |
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| Zhou Yuan1,Chen Yuan1,Shao Bingfeng1,Zhang Suqing1,Zhang Yixin1,Wu Yaxun2,Yin Bihui3,Zhu Xinguo4. The expression and correlation of Bcl-2 and Beclin-1 in hepatocellular carcinoma[J]. Journal of Modern Oncology, 2018, 0(20): 3263-3267. DOI: 10.3969/j.issn.1672-4992.2018.20.022 |
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| Authors: | Zhou Yuan1 Chen Yuan1 Shao Bingfeng1 Zhang Suqing1 Zhang Yixin1 Wu Yaxun2 Yin Bihui3 Zhu Xinguo4 |
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| Affiliation: | 1.Hepatology Department;2.Pathology Department,Tumor Hospital of Nantong,Jiangsu Nantong 226300,China;3.Graduate School,Medical School of Nantong University,Jiangsu Nantong 226001,China;4.General Surgery Department,the First Affiliated Hospital of Soochow |
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| Abstract: | Objective:To investigate the role of Bcl-2 and Beclin-1 in the recurrence of hepatocellular carcinoma (HCC) after surgery,and analyze the correlation between them.Methods:Bcl-2 and Beclin-1 protein expression in HCC were confirmed using immunohistochemistry on a tissue microarray chip.These expressions were correlated with conventional clinicopathological features of HCC.Results:The comparison of clinicopathological characteristics and immunohistochemistry by χ2 test analysis showed that the expression of Bcl-2 in HCC was related to tumor gross classification and the expression of Beclin-1 in HCC was only related to tumor differentiation.The correlation between Bcl-2 and Beclin-1 protein expression in HCC was negative (r=-0.61,P＜0.000 1).Log-rank regression analysis showed that the high-expression level of Bcl-2 and the low-expression level of Beclin-1 could separately affect the prognosis of patients.Multivariable regression analysis showed that disease-free survival (DFS) was significantly associated with tumor gross classification and Bcl-2 expression level.Conclusion:Bcl-2 expression is negatively correlated with Beclin-1 expression in HCC tissue.The Bcl-2 and Beclin-1 expression affect the prognosis of HCC patients. |
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| Keywords: | hepatocellular carcinoma Bcl-2 Beclin-1 apoptosis autophagy |
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