Hematologic Toxicity of Conformal Radiotherapy and Intensity Modulated Radiotherapy in Prostate and Bladder Cancer Patients |
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| Authors: | Marcin Miszczyk1Wojciech Majewski2 |
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| Affiliation: | 1Department of Radiotherapy Planning, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland.2Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland. |
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| Abstract: | Background: The purpose of this study was to compare hematologic adverse effects and hematologic toxicity(HT) of pelvic irradiation in patients treated with conformal radiotherapy (CRT) and intensity modulated radiotherapy(IMRT) for radical treatment of prostate and bladder cancer. Methods: A group of 115 patients with prostate or bladdercancer treated with definitive radical radiotherapy was evaluated retrospectively. Blood test were taken before andafter treatment comprising of following indices: white blood cells (WBC) hemoglobin (HGB), red blood cell (RBC),lymphocyte (LC), neutrophil (NC) and platelet (PLT) count. Patients were divided into several subgroups and the datawas evaluated statistically using absolute and relative values. Results: There was a statistically significant differencein WBC (p=0.007), NC (p=0.031) and PLT (p=0.026) count decrease (absolute values) after treatment, between twotreatment methods (CRT and IMRT), all in favor of IMRT. The relationship still proves to be significant regardingWBC (p=0,02) and (NC) (p=0,049) after presenting the data as relative percentage loss of starting value. Howeverusing Common Terminology Criteria for Adverse Effects (CTCAE), PLT count toxicity was more common in IMRTgroup (p=0.045). Conclusion: IMRT in comparison to CRT in bladder and prostate cancer patients is associated with alesser absolute and relative decrease of hematologic indices. The hematologic effect of radiation was observed mainlyregarding LC. Patients treated with IMRT suffered from significantly lesser decrease in relative and absolute valuesof WBC and NC. The mean of absolute PLT decrease count was lower in IMRT group; however, toxicity according toCTCAE was slightly more prevalent in IMRT group. |
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| Keywords: | Prostatic Neoplasms Urinary Bladder Neoplasms Radiotherapy Intensity-Modulated Radiotherapy Conformal Hematologic Toxicity |
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