| 金纳米粒子在肿瘤放疗中的研究进展 |
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| 引用本文： | 常静林,张玉民,董辉. 金纳米粒子在肿瘤放疗中的研究进展[J]. 国际放射医学核医学杂志, 2018, 42(3): 261-264. DOI: 10.3760/cma.j.issn.1673-4114.2018.03.012 |
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| 作者姓名： | 常静林 张玉民 董辉 |
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| 作者单位： | 300192 天津, 中国医学科学院北京协和医学院放射医学研究所, 天津市放射医学与分子核医学重点实验室 |
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| 基金项目： | 中国医学科学院医学与健康科技创新工程项目2016-I2M-3-022 协和青年基金资助和中央高校基本科研业务费专项资金资助3332015100 |
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| 摘 要： | 放疗在肿瘤的治疗中起着不可替代的作用，但由放疗引起的不良反应以及放疗过程中的肿瘤耐受问题仍未得到根本解决，因此放疗增敏显得尤为重要。金纳米粒子（GNPs）作为新型的纳米类放疗增敏制剂，因其较高的生物相容性受到了专家学者的广泛关注和研究。作为新型的纳米制剂，GNPs的理化性质，包括粒径、表面电荷和组装形态等能够影响体内代谢行为和肿瘤蓄积，因此导致放疗增敏率不同。笔者对近几年GNPs作为放疗增敏制剂的研究进展做进一步的总结和进展性汇报。
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| 关 键 词： | 纳米粒子 金 肿瘤 放射疗法 增敏 |
| 收稿时间： | 2017-12-14 |
Advances in the application of gold nanoparticles in tumor radiotherapy |
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| Jinglin Chang,Yumin Zhang,Hui Dong. Advances in the application of gold nanoparticles in tumor radiotherapy[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2018, 42(3): 261-264. DOI: 10.3760/cma.j.issn.1673-4114.2018.03.012 |
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| Authors: | Jinglin Chang Yumin Zhang Hui Dong |
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| Affiliation: | Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin 300192, China |
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| Abstract: | Even though radiotherapy plays an important role in the treatment of tumors, the problems of toxic and side effects of normal tissues produced by radiotherapy and tumor tolerance to irradiation have not been solved. Gold nanoparticles(GNPs) are a new type of nanoparticle radiosensitizer. As a radiosensitizer, GNPs have become the focus of research because of their high biocompatibility. Their physical and chemical properties(including size, surface charge, and shape) can affect their metabolism behavior and tumor accumulation, thereby resulting in different sensitizing effect of radiotherapy. This review will summarize the progress of recent research on GNPs as a radiosensitizer. |
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| Keywords: | Nanoparticles Gold Neoplasms Radiotherapy Sensitization |
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