Serum amyloid P component binding to Shiga toxin 2 requires both a subunit and B pentamer |
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| Authors: | Marcato Paola Vander Helm Kathleen Mulvey George L Armstrong Glen D |
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| Affiliation: | Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. |
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| Abstract: | Solid-phase binding, competitive binding, and cytotoxicity neutralization assays indicate that the B pentamer and A subunit both contribute to human serum amyloid P (HuSAP) component binding to Stx2. A polyvalent globotriaosyl-ceramide receptor analog, Daisy, did not competitively inhibit HuSAP binding, implying that the two ligands bind to different Stx2 domains. |
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