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Successful treatment of hepatitis E virus‐associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin
Authors:A. Del Bello  C. Guilbeau‐Frugier  A.‐G. Josse  L. Rostaing  J. Izopet  N. Kamar
Affiliation:1. Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France;2. Université Paul Sabatier, Toulouse, France;3. Department of Pathology, CHU Rangueil, Toulouse, France;4. Clinique du Pont De Chaume, Montauban, France;5. INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France;6. Laboratory of Virology, CHU Purpan, Toulouse, France
Abstract:Hepatitis E virus genotype‐3 (HEV3) infection can cause chronic hepatitis in immunosuppressed patients and induce extra‐hepatic manifestations, such as neurological symptoms, kidney injuries, and immune‐mediated thrombocytopenia. Very few cases of HEV‐induced kidney manifestations have been reported. Herein, we report, for the first time, a case of de novo membranoproliferative glomerulonephritis that occurred in a kidney transplant patient who developed a chronic HEV3 infection, which was successfully treated with ribavirin.
Keywords:kidney transplantation  membranoproliferative glomerulonephritis  hepatitis E virus  ribavirin  de novo glomerulopathy
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