| 多种胃肠激素对肠易激综合征患者小肠运动功能的研究 |
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| 引用本文： | 赵菊辉,董蕾,郝筱倩. 多种胃肠激素对肠易激综合征患者小肠运动功能的研究[J]. 南方医科大学学报, 2007, 27(10): 1492-1495 |
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| 作者姓名： | 赵菊辉 董蕾 郝筱倩 |
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| 作者单位： | 西安交通大学第二医院消化内科,陕西,西安,710004;西安交通大学第二医院消化内科,陕西,西安,710004;西安交通大学第二医院消化内科,陕西,西安,710004 |
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| 摘 要： | 目的 观察血浆胃肠激素的变化与肠易激综合症(IBS)患者小肠消化间期移行性复合运动(MMC)的关系以及在IBS发病过程中的可能作用和临床意义.方法 10名健康对照者及19例IBS患者禁食6 h以上,用灌注式小肠测压管测压,并在小肠MMCI、Ⅱ和Ⅲ相采集静脉血进行血浆胃动素、生长抑素及5-HT的血浆浓度测定.结果 腹泻型IBS患者小肠消化间期MMC周期缩短、Ⅲ相波幅升高、时程延长,传导速度加快;便秘型IBS患者则相反.①血浆胃动素水平在MMC Ⅲ相升高,各组间Ⅲ相胃动素水平差异有统计学意义.②IBS组血浆生长抑素浓度显著高于对照组,而腹泻组和便秘组之间没有差异.③各组血浆5-HT水平均随MMC发生周期性的变化,Ⅱ相血浆5-HT水平达峰值.3组间相比,IBS腹泻组血浆5-HT水平升高,与便秘组和对照组比较差异有统计学意义(P＜0.05).结论 胃肠激素紊乱和小肠动力异常在IBS发病中可能起着重要的作用.
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| 关 键 词： | 肠易激综合征 消化间期移行性复合运动 胃动素 生长抑素5-羟色胺 |
| 文章编号： | 1673-4254（2007）10-1492-04 |
| 修稿时间： | 2007-06-04 |
Small intestine motility and gastrointestinal hormone levels in irritable bowel syndrome |
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| ZHAO Ju-hui,DONG Lei,HAO Xiao-qian. Small intestine motility and gastrointestinal hormone levels in irritable bowel syndrome[J]. Journal of Southern Medical University, 2007, 27(10): 1492-1495 |
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| Authors: | ZHAO Ju-hui DONG Lei HAO Xiao-qian |
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| Affiliation: | Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China. |
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| Abstract: | OBJECTIVE: To investigate the relationship between interdigestive migrating motor complex (MMC) and plasma gastrointestinal hormones in patients with diarrhea or constipation-predominant irritable bowel syndrome (IBS) to elucidate the pathophysiology of IBS. METHODS: A small intestine manometry was used to record the MMC cycles for at least 4-6 h in 19 IBS patients and 10 healthy volunteers. The plasma gastrointestinal hormone levels were examined according to altered MMC phases. RESULTS: Compared with the healthy controls, IBS-D patients exhibited shortened duration of the small intestinal MMC cycle, prolonged phase III duration with greater amplitude, as well as faster propagation velocity, whereas the contrary alterations were found in IBS-C patients. The peak plasma motilin level occurred in phase III of the MMC cycle. The plasma somatostatin level was higher in IBS groups than in the healthy controls, but comparable between the diarrhea and constipation groups. Plasma 5-hydroxytryptamine showed periodical fluctuations with the phases of MMC cycles, reaching the peak level in phase II. IBS-D patients had higher 5-hydroxytryptamine levels than IBS-C patients and the healthy controls. CONCLUSIONS: Plasma hormone levels are correlated with the MMC cycles, and the hormone level changes and small intestine motility disorder may play important roles in IBS pathophysiology. |
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| Keywords: | irritable bowel syndrome motor complex migrating motilin somatostatin 5-hydroxytryptamine |
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