| 氨噻肟唑头孢菌素的合成 |
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| 引用本文： | 氨噻肟唑头孢菌素的合成[J]. 中国药科大学学报, 1985, (1): 1-3. |
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| 作者姓名： | 李明华 程建明 闻琍毓 何冰芳 刘正春 段廷汉 |
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| 作者单位： | 南京药学院制药化学教研室，南京药学院制药化学教研室，南京药学院制药化学教研室，南京药学院制药化学教研室，南京药学院制药化学教研室，南京药学院制药化学教研室 1982届毕业生，1982届毕业生 |
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| 摘 要： | 本文以7-ACA为原料制备了7-ACT,再以DCC为缩合剂与侧链2(2-氯乙酰氨基噻唑-4)-(Z)-2甲氧亚胺乙酸进行缩合,使用N-甲基二硫代氨基甲酸甲胺盐脱保护基,以葡聚糖凝胶LH-20精制合成了氨噻肟唑头孢菌素;总收率35.8％。产物经~1H核磁确证为顺式构型化合物。
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| 关 键 词： | 氨噻肟唑 SCE-1365 头孢菌素 |
SYNTHESIS OF CEFMENOXIME |
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| SYNTHESIS OF CEFMENOXIME[J]. Journal of China Pharmaceutical University, 1985, (1): 1-3. |
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| Authors: | Li Minghu Cheng Jianming Wen Liyu He Bingfang Liu Zhengchun Duan Tinghan |
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| Affiliation: | Li Minghua;Cheng Jianming;Wen Liyu;He Bingfang;Liu Zhengchun;Duan Tinghan Department of Pharmaceutical Chemistry Students of 1982 |
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| Abstract: | Cefmenoxime was synthesized by a four-step method with overall yield of 35.80%. The conversion of 7-ACA to 7-ACT with 1-methyl-1H-tetrazole-5-thiol, the condensation of the side-chain 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-me- thoxyimino-acetic acid with DCC as condensing agent, the removal of the pro- tecting group with N-methyl-dithiocarbamate methyl amine salt and the purifi- cation of the crude product on sephadex IH-20 column were processed. |
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| Keywords: | Cefmenoxime Cephalosporin 7-ACA |
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