| 利用SPSS估算血管外给药的药动学参数 |
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| 引用本文： | 莫志江. 利用SPSS估算血管外给药的药动学参数[J]. 中国现代应用药学, 2005, (3): 221-224. |
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| 作者姓名： | 莫志江 |
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| 作者单位： | 广西壮族自治区人民医院药剂科,广西,南宁,530021 |
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| 摘 要： | 目的 利用SPSS估算血管外给药室模型的药动学参数。方法使用SPSS的非线性回归(nonlinear regression)拟合模拟的两室模型血管外给药的药-时数据；依据95％置信区间决定是否在模型中保留滞后时间(tlag)项。结果SPSS估算的药动学参数：住确可靠；根据tlag95％置信区间决定是否在模型中保留flag项是合理的。结论SPSS适用于估算血管外给药室模型的药动学参数。
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| 关 键 词： | 非线性回归 SPSS 药动学参数 拟合 血管外给药 |
| 文章编号： | 1007-7693(2005)03-0221-04 |
Estimating the pharmacokinetic parameters in extravascular administration by SPSS |
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| MO Zhi-jiang. Estimating the pharmacokinetic parameters in extravascular administration by SPSS[J]. Chinese Journal of Modern Applied Pharmacy, 2005, (3): 221-224. |
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| Authors: | MO Zhi-jiang |
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| Abstract: | OBJECTIVE To estimate the pharmacokinetic parameters of compartment models with extravascular administration using SPSS.METHOD Concentration-time data from the simulation of two-compartment model with the 1st order absorption and lag time( t _ lag ) were fitted using SPSS nonlinear regression. 95% confidence interval (95% CI) for t _ lag was used to determine if t _ lag item remained in the model.RESULTS The pharmacokinetic parameters obtained from SPSS were exact and reliable. It was reasonable to determine if t _ lag item remains in the model according to its 95% CI.CONCLUSION SPSS is suitable for estimating the pharmacokinetic parameters of compartment models with extravascular administration. |
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| Keywords: | nonlinear regression SPSS pharmacokinetic parameters fit extravascular administration |
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