| 比索洛尔对高血压病并发慢性心力衰竭患者脑钠尿肽前体的影响 |
| |
| 引用本文： | 葛坤文,钟太敏. 比索洛尔对高血压病并发慢性心力衰竭患者脑钠尿肽前体的影响[J]. 心脏杂志, 2016, 28(6): 694-696 |
| |
| 作者姓名： | 葛坤文 钟太敏 |
| |
| 作者单位： | （高州市金山医院内科，广东 高州 525259） |
| |
| 摘 要： | 目的 探讨比索洛尔对高血压病并发慢性心力衰竭（CHF）患者脑钠尿肽（BNP）前体（Pro-BNP)的影响。方法 选取我院收治的高血压病并发CHF的患者102例，随机分为试药组和对照组各51例。对照组按照高血压病并发CHF的常规治疗方案进行干预，试药组在对照组治疗方案的基础上，加用比索洛尔口服治疗。治疗3个月后对比两组患者的心功能改善情况，同时对比两组患者治疗前后的心率、血压、左室射血分数(LVEF)以及pro-BNP的变化情况。结果 试药组的显效率为49%，总有效率为96%，均显著高于对照组（分别为29%，76%，均P<0.05）；两组患者治疗后的心率、收缩压和舒张压均显著低于治疗前，而LVEF显著高于治疗前（均P<0.05）；试药组治疗后的LVEF为（44±4）%，显著高于对照组〔（35±4）%，P<0.05〕；试药组治疗后的Pro-BNP水平为（733±58） ng/L，对照组治疗后的Pro-BNP水平为（802±63） ng/L，两组患者治疗后的Pro-BNP水显著低于治疗前（均P<0.05）；试药组治疗后的Pro-BNP水平显著低于对照组（P<0.05）。结论 比索洛尔可有效降低高血压病并发CHF患者的Pro-BNP水平，提高临床疗效。
|
| 关 键 词： | 比索洛尔 高血压，原发性 心力衰竭，慢性 脑钠尿肽前体 |
| 收稿时间： | 2015-09-11 |
Effect of bisoprolol on ProBNP in patients with hypertension combined with chronic heart failure |
| |
| Abstract: | AIM To investigate the effects of bisoprolol on brain natriuretic peptide (BNP) in patients with hypertension combined with chronic heart failure (CHF) and to provide a theoretical basis for the formulation of clinical treatment. METHODSOne hundred and two hypertensive patients combined with CHF in our hospital were randomly divided into observation group and control group (51 cases in each group). The control group received conventional treatment and the observation group received conventional treatment plus bisoprolol. After 3 months of treatment, improvement of heart function of the two groups was compared and changes of heart rate, blood pressure, left ventricular ejection fraction and BNP before and after treatment were also compared between groups. RESULTSThe total effective rate in the observation group was 96.08%, significantly higher than in the control group (P<0.05). In both groups, heart rate, systolic blood pressure and diastolic blood pressure were significantly lower, whereas left ventricular ejection fraction was significantly higher than before treatment (P<0.05). Left ventricular ejection fraction in observation group was significantly higher than in control group. BNP levels in both groups decreased markedly after treatment (both P<0.05) and the level in the observation group was significantly lower than the control group (P<0.05). CONCLUSIONBisoprolol can effectively reduce the level of BNP in hypertensive patients combined with CHF, promote curative effects and improve heart function. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
|
点击此处可从《心脏杂志》下载免费的PDF全文 |
|
