| Effects of a Herbal Formula on Biochemical Markers of Bone Turnover in Ovariectomized Rats |
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| 引用本文： | 徐敏,谢金华,张晓晖,Warren Kett,Richard Prince,冯新送. Effects of a Herbal Formula on Biochemical Markers of Bone Turnover in Ovariectomized Rats[J]. 中国结合医学杂志, 2002, 8(1) |
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| 作者姓名： | 徐敏 谢金华 张晓晖 Warren Kett Richard Prince 冯新送 |
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| 作者单位： | 徐敏(Guangzhou University of Traditional Chinese Medicine, Guangzhou (510405)P.R . China; University of Western Australia, WA 6009, Australia; Chinese Univ ersity of Hong Kong, Hong Kong);谢金华,张晓晖,冯新送(Guangzhou University of Traditional Chinese Medicine, Guangzhou (510405)P.R . China);Warren Kett,Richard Prince(Chinese Univ ersity of Hong Kong, Hong Kong) |
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| 基金项目： | ItisapartoftheresearchoftheChinese AustralianGovernmentJointProject(1997 C12 )supportedbyGuangdong，GuangzhouCouncilofScienceandTechnologyandUniversityofWesternAustrali a |
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| 摘 要： |
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Effects of a Herbal Formula on Biochemical Markers of Bone Turnover in Ovariectomized Rats |
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| Warren Kett,Richard Prince. Effects of a Herbal Formula on Biochemical Markers of Bone Turnover in Ovariectomized Rats[J]. Chinese journal of integrative medicine, 2002, 8(1) |
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| Authors: | Warren Kett Richard Prince |
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| Abstract: | Objective: To investigate the effect and mechanism of a Chinese herbal fo rmula MG in ameliorating estrogen deficiency bone loss. Methods: 1 0-month old female rats were randomly divided into three groups: ovariectomized (OVX), OVX treated with MG decoction (OVX-M) and OVX treated with estrogen injection (OVX-E). The urinary pyridinoline creatinine ratio (Pyd/Cr), deoxypyridinoline creatinine ratio (Dpd/Cr), and plasma alkaline phosphatase (ALP) were determined at the baseline, 1, 4, 8 and 12 postoperative weeks. Results: Our data showed an average increase of 93% in Pyd/Cr ( P<0.001), 180% in Dp d/Cr (P<0.005) and 59% in plasma ALP (P<0.001) respectively in the OVX group after o variectomy. Compared with OVX rats, the increase of the OVX-M group were preven t ed 39% in Pyd/Cr, 102% in Dpd/Cr and 19% in ALP respectively (P<0.05). Co nclusion: The herbal formula MG possesses a therapeutic effect on estrog en dependent bone loss by inhibiting the bone turnover as estrogen replacement. |
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| Keywords: | Chinese herb bone marker ovariectomized rat |
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