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| 伊马替尼治疗慢性粒细胞白血病患者在生育时中断药物治疗对胎儿和患者自身的影响 | |
| 引用本文： | 梁顺玉,潘耀柱,杨柯,白海. 伊马替尼治疗慢性粒细胞白血病患者在生育时中断药物治疗对胎儿和患者自身的影响[J]. 现代肿瘤医学, 2020, 0(1): 113-116. DOI: 10.3969/j.issn.1672-4992.2020.01.028 |
| 作者姓名： | 梁顺玉 潘耀柱 杨柯 白海 |
| 作者单位： | 中国人民解放军联勤保障部队第九四〇医院血液病内科，甘肃 兰州 730050 |
| 基金项目： | 国家自然科学基金(编号:81372132);甘肃省青年科技计划(编号:17JR5RA326) |
| 摘 要： | 目的:分析伊马替尼治疗慢性粒细胞白血病（chronic myeloid leukemia，CML）患者在生育时中断药物治疗对胎儿和患者自身的影响。方法:回顾性分析本科室21例CML合并妊娠患者在接受伊马替尼治疗后的影响。结果:21名接受伊马替尼治疗的CML患者中有6名为意外怀孕，15名为计划怀孕。有生育意愿的女性患者需达到血液学或细胞学缓解至少两年，在受孕前1个月和孕期前3个月停服伊马替尼，男性患者则在生育前一个月停止接受伊马替尼的治疗。所有意外受孕的患者在孕期均未停止服用伊马替尼。21名患者共生产9名男婴和7名女婴（其中1名尿道下裂，1名轻度脑水肿），其余有2名自然流产，3名选择性流产。结论:鼓励接受伊马替尼治疗的CML患者有计划的生育，对于治疗期间意外怀孕的患者，伊马替尼则会导致自然流产或先天性异常。 |
| 关 键 词： | 伊马替尼 慢性粒细胞白血病 妊娠 |
The effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients |
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| Liang Shunyu,Pan Yaozhu,Yang Ke,Bai Hai. The effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients[J]. Journal of Modern Oncology, 2020, 0(1): 113-116. DOI: 10.3969/j.issn.1672-4992.2020.01.028 | |
| Authors: | Liang Shunyu Pan Yaozhu Yang Ke Bai Hai |
| Affiliation: | Department of Hematology，the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army，Gansu Lanzhou 730050，China. |
| Abstract: | Objective:To analyze the effect of discontinuation of imatinib in the treatment of chronic myeloid leukemia in pregnancy on fetus and patients.Methods:Retrospect the impact of 21 CML patients complicated with pregnancy in our department during receiving imatinib.Results:Of the 21 CML patients who received imatinib,6 were accidentally pregnancies and 15 were planed to become pregnant.Female patients with fertility will need to achieve hematologic or cytological remission for at least 2 years,stop imatinib 1 month before conception and 3 months before pregnancy.Male patients stop receiving imatinib 1 month before their wife become pregnant.All patients who were accidentally conceived did not stop taking imatinib during pregnancy.Without 2 spontaneous abortions and 3 elective abortions.All 21 patients produced 9 male and 7 female infants(1 with hypospadias and 1 mild cerebral edema).Conclusion:CML patients receiving imatinib are encouraged to have planned pregnancy,and imatinib may cause spontaneous abortion or congenital anomalies in patients who are unintended during treatment. |
| Keywords: | imatinib chronic myeloid leukemia pregnant |
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