| 移植物抗宿主病的治疗及移植相关肝损伤的研究进展 |
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| 引用本文： | 白伟,徐孟媛,周晋. 移植物抗宿主病的治疗及移植相关肝损伤的研究进展[J]. 现代肿瘤医学, 2022, 0(6): 1138-1141. DOI: 10.3969/j.issn.1672-4992.2022.06.040 |
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| 作者姓名： | 白伟 徐孟媛 周晋 |
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| 作者单位： | 哈尔滨医科大学附属第一医院,黑龙江 哈尔滨 150001 |
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| 摘 要： | 异基因造血干细胞移植使治愈血液系统恶性疾病成为可能.但在移植后出现的移植物抗宿主病及重要脏器损伤越来越成为移植后的主要并发症及非复发死亡的重要原因.目前移植物抗宿主病的治疗以免疫抑制为主,但部分患者疗效欠佳,并可能减弱移植物抗白血病效应、增加感染机会.对于如何预防及早期识别移植物抗宿主病,不同药物方案对比以及对于肝脏相...
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| 关 键 词： | 异基因造血干细胞移植 GVHD处理方案 GVHD预测 肝脏并发症 GVHD的治疗(糖皮质激素与西罗莫司) |
Research progress in the treatment of graft versus host disease and transplant-related liver injury |
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| BAI Wei,XU Mengyuan,ZHOU Jin. Research progress in the treatment of graft versus host disease and transplant-related liver injury[J]. Journal of Modern Oncology, 2022, 0(6): 1138-1141. DOI: 10.3969/j.issn.1672-4992.2022.06.040 |
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| Authors: | BAI Wei XU Mengyuan ZHOU Jin |
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| Affiliation: | The First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150001,China. |
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| Abstract: | Allogeneic hematopoietic stem cell transplantation makes it possible to cure malignant diseases of the blood system.However,graft versus host disease and important organ damage appearing after transplantation have become the main complications and important causes of non-recurring death after transplantation.At present,the treatment of graft versus host disease is mainly immunosuppression,but some patients have poor curative effects and may weaken the anti-leukemia effect of the graft and increase the chance of infection.For the prevention and early identification of graft versus host disease,comparison of different drug regimens,and research and treatment of liver-related injuries have become hot topics.This article reviews the prevention,prediction,and treatment of graft versus host disease,transplant-related liver injury,and the prospects for hematopoietic stem cell transplantation. |
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| Keywords: | allogeneic hematopoietic stem cell transplantation GVHD treatment plan GVHD prediction liver complications GVHD treatment(glucocorticoids and sirolimus) |
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