Restricted expression of FcγRIII (CD16) in synovium and dermis: implications for tissue targeting in rheumatoid arthritis (RA) |
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| Authors: | J C W EDWARDS S BLADES G CAMBRIDGE |
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| Affiliation: | Centre for Rheumatology, University College London, London, UK |
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| Abstract: | Interactions between immune complexes and immunoglobulin Fc receptors may contribute to inflammation in RA. Previous studies suggested that FcγRIII (CD16) may be preferentially expressed in diseased synovial intima. The distribution of immunoreactive FcγRIII was examined in normal fetal limb tissues, and both normal and selected abnormal samples of adult synovium and skin. In fetal limbs at 10–14 weeks gestation FcγRIII was restricted to synovial intima. In normal adult synovium FcγRIII was restricted to intimal cells. In inflamed synovia differential expression of FcγRIII in the intima was less consistent. In both fetal and adult synovium FcγRIII was largely restricted to cells expressing CD45 (leucocyte common antigen). Staining for FcγRIII was, however, occasionally associated with CD45− intimal cells in fetal synovium. In both fetal and adult tissues cell membrane FcγRIII was frequently closely associated with complement decay-accelerating factor (DAF), which is present on intimal fibroblasts and extracellular matrix. FcγRIII expression was minimal in normal forearm dermis, but widespread on CD45+ cells in skin exposed to mechanical stress. In skin containing rheumatoid nodules, FcγRIII was preferentially expressed on palisading macrophages. These observations indicate that expression of FcγRIII on macrophages may be involved in the susceptibility of connective tissues to immune complex-induced damage in RA. Colocalization of FcγRIII and DAF in synovium may indicate an unrecognized functional interrelationship. |
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| Keywords: | synovium CD16 macrophage fetal rheumatoid arthritis |
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