| RRBP1与RABEX-5蛋白在结直肠癌组织中的表达及与临床病理特征和预后的关系 |
| |
| 引用本文： | 廖代祥,郑博,张彦斌,于军辉. RRBP1与RABEX-5蛋白在结直肠癌组织中的表达及与临床病理特征和预后的关系[J]. 实用肿瘤学杂志, 2020, 34(1): 43-48. DOI: 10.11904/j.issn.1002-3070.2020.01.008 |
| |
| 作者姓名： | 廖代祥 郑博 张彦斌 于军辉 |
| |
| 作者单位： | 1.北京市门头沟区医院肿瘤科(北京 102300);2.北京市门头沟区医院肛肠科;3.首都医科大学附属北京世纪坛医院肿瘤外科三区 |
| |
| 摘 要： | 目的探讨核糖体结合蛋白1(RRBP1)与RABEX-5蛋白在结直肠癌组织中的表达与临床病理特征和预后的关系。方法 2015年8月—2016年8月收集外科手术治疗的86例结直肠癌患者的癌组织标本及相对应的癌旁组织标本;采用免疫组化染色法检测所有研究对象RRBP1、RABEX-5蛋白的表达水平,分析RRBP1、RABEX-5蛋白表达与结直肠癌患者临床病理特征的关系;并采用Cox比例风险模型分析影响结直肠癌患者预后的相关因素。结果结直肠癌癌组织中RRBP1、RABEX-5蛋白阳性表达率(65.12%和62.79%)明显高于结肠癌癌旁组织RRBP1、RABEX-5蛋白阳性表达率(38.37%和36.05%),差异有统计学意义(P<0.001);TNMⅢ～Ⅳ期、肿瘤低分化、出现淋巴转移时结直肠癌患者PRRBP1、RABEX-5阳性表达率均升高(P<0.05);RRBP1阳性表达和阴性表达的中位总生存期分别为30个月和20个月,RABEX-5阳性表达和阴性表达中位总生存期分别为31个月和19个月;经单因素与多因素分析结果显示,TNMⅢ～Ⅳ期、肿瘤低分化、淋巴转移、RRBP1阳性表达、R...
|
| 关 键 词： | 核糖体结合蛋白1 RABEX-5 结直肠癌 临床病理特征 预后 |
| 收稿时间： | 2019-09-05 |
Expression of RRBP1 and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis |
| |
| LIAO Daixiang,ZHENG Bo,ZHANG Yanbin,YU Junhui. Expression of RRBP1 and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis[J]. Journal of Practical Oncology, 2020, 34(1): 43-48. DOI: 10.11904/j.issn.1002-3070.2020.01.008 |
| |
| Authors: | LIAO Daixiang ZHENG Bo ZHANG Yanbin YU Junhui |
| |
| Affiliation: | 1.Department of Oncology,Beijing Men Tou Gou District Hospital,Beijing 102300,China;2.Department of Anorectal Surgery,Beijing Men Tou Gou District Hospital;3.Department of Surgical Oncology,Ward 3rd,Beijing Shijitan Hospital,Capital Medical University |
| |
| Abstract: | Objective The aim of this study was to investigate the expression of ribosomal binding protein 1(RRBP1)and RABEX-5 proteins in colorectal cancer and their correlation with clinicopathological features and prognosis.Methods Colorectal cancer tissue specimens and paracancerous tissue specimens from 86 patients with colorectal cancer who underwent surgical treatment were collected from August 2015 to August 2016.Immunohistochemical staining was used to detect the levels of RRBP1 and RABEX-5 proteins.The relationship between the expression of RRBP1 and RABEX-5 protein and clinicopathological features of patients with colorectal cancer was analyzed.Cox proportional hazard analysis was used to analyze the associated factors of colorectal cancer patients affecting prognosis.Results The positive expression rates of RRBP1 and RABEX-5 proteins in colorectal cancer tissues were 65.12%and 62.79%,respectively.The positive expression rates of RRBP1 and RABEX-5 proteins in colorectal adjacent tissues were 38.37%and 36.05%,respectively.There were significant differences in the positive expression rates of RRBP1 and RABEX-5 proteins(P<0.001).The positive expression rates of RRBP1 and RABEX-5 in colorectal cancer patients with stageⅢ-ⅣTNM,poor tumor differentiation and lymphatic metastasis were increased(P<0.05).The median overall survival time of RRBP1 positive and negative expression was 30 months and 20 months,respectively.The median overall survival time of RABEX-5 positive and negative expression was 31 months and 19 months,respectively.The results of univariate and multivariate analyses showed that TNM stageⅢ-Ⅳ,tumor subdivision,lymphatic metastasis,RRBP1 positive expression and RABEX-5 positive expression were independent factors affecting the prognosis of patients with colorectal cancer(P<0.01).Conclusion The levels of RRBP1 and RABEX-5 proteins in colorectal cancer tissues are increased,positively correlated with TNM stage and lymphatic metastasis of colorectal cancer patients,and negatively correlated with the degree of differentiation.The positive expression of RRBP1 and RABEX-5 proteins is a risk factor for the prognosis of colorectal cancer patients,and they can be used as effective biomarkers for diagnosis and prognosis of colorectal cancer. |
| |
| Keywords: | RRBP1 RABEX-5 Colorectal cancer Clinicopathological features Prognosis |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《实用肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《实用肿瘤学杂志》下载免费的PDF全文 |
|
