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| 绝经后妇女甲状旁腺素基因多态性与骨密度：福州地区的调查 | |
| 引用本文： | 谢丽华,倪晨波,李生强,陈 娟,许惠娟,赖玉链,葛继荣. 绝经后妇女甲状旁腺素基因多态性与骨密度：福州地区的调查[J]. 中国组织工程研究, 2013, 17(50): 8641. DOI: 10.3969/j.issn.2095-4344.2013.50.004 |
| 作者姓名： | 谢丽华 倪晨波 李生强 陈 娟 许惠娟 赖玉链 葛继荣 |
| 作者单位： | 福建省中医药研究院基础医学研究所,福建省福州市 350003 |
| 基金项目： | 国家自然科学基金资助项目(81173280)*;福建省卫生厅医学创新课题资助(2011-CX-30)*;福建省中医药研究院自主选题(2012fjzyyk-5)* |
| 摘 要： | 背景：有研究证实,绝经后妇女骨密度与甲状旁腺素基因有密切关系,但在不同地区人群中结果存在差异性。目的：探讨福州地区绝经后妇女甲状旁腺素基因(PTH)BstBⅠ多态性与骨密度的关系。方法：用双能X射线骨密度仪检测福州地区150例绝经后妇女的腰椎、股骨颈,大转子和Ward’s三角骨密度,应用PCR-RFLP技术检测甲状旁腺素基因BstBⅠ多态性。结果与结论：①甲状旁腺素基因型分布频率为BB型 68.8%、Bb型24.1%、bb 型7.1%。等位基因频率为B 81%,b 19%,基因型分布符合Hardy-Weinberg定律。②分析其基因型与骨密度的关系：BB、Bb、bb 3种基因型在股骨颈、大转子、Ward’s三角区4个部位骨密度差异均无显著意义(P > 0.05)。甲状旁腺素基因BstBⅠ位点多态性与骨密度间无关联,尚不能作为预测福州地区绝经后妇女发生骨质疏松危险的遗传标志。中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接： |
| 关 键 词： | 组织构建 骨组织构建 绝经后 骨质疏松症 骨密度 甲状旁腺素基因 多态性 福州地区 国家自然科学基金 |
The association between polymorphism of parathyroid hormone gene and bone mineral density in Fuzhou postmenopausal women |
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| Xie Li-hua,Ni Chen-bo,Li Sheng-qiang,Chen Juan,Xu Hui-juan,Lai Yu-lian,Ge Ji-rong. The association between polymorphism of parathyroid hormone gene and bone mineral density in Fuzhou postmenopausal women[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(50): 8641. DOI: 10.3969/j.issn.2095-4344.2013.50.004 | |
| Authors: | Xie Li-hua Ni Chen-bo Li Sheng-qiang Chen Juan Xu Hui-juan Lai Yu-lian Ge Ji-rong |
| Affiliation: | Department of Basic Medicine, Fujian Institute of Chinese Medicine, Fuzhou 350003, Fujian Province, China |
| Abstract: | BACKGROUND: Studies have shown the bone mineral density of postmenopausal women is closely related to parathyroid hormone. But there are differences in different areas.OBJECTIVE:To investigate the association between BstBⅠ polymorphism of parathyroid hormone gene with bone mineral density in postmenopausal women from Fuzhou area.METHODS:The bone mineral densities of the lumbar spine, femoral neck, trochanter and Ward’s triangle were measured in 150 postmenopausal women by dual energy X-ray absorptiometry. The genotype of parathyroid hormone gene was determined by polymerase chain reaction-restriction fragment length polymorphism.RESULTS AND CONCLUSION: (1) The distribution of parathyroid hormone genotypes were BB genotype 68.8%, Bb 24.1%, and bb 7.1%. The B allelic gene frequencies reached 81%, while b was 19%. The distribution followed the Hardy-Weinberg equilibrium. (2) Analysis of the relationship between the genotypes and bone mineral density: There was no significant difference in the bone mineral densities of the lumbar spine, femur, neck, trochanter and Ward’s triangle among the three genotypes (P > 0.05). BstBⅠ gene polymorphism of parathyroid hormone gene is not correlated to bone mineral density, and there is no enough evidence to support genotype of parathyroid hormone gene as a genetic marker in predicting the risk of developing osteoperosis in Fuzhou postmenopausal women. |
| Keywords: | osteoporosis postmenopausal bone density parathyroid hormone genes femur neck lumbar vertebrae |
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