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| 正电子发射计算机断层显像/核磁共振：分子影像学技术新进展 | |
| 引用本文： | 张敏燕,王殊轶,严荣国,葛 斌,周 颖. 正电子发射计算机断层显像/核磁共振：分子影像学技术新进展[J]. 中国组织工程研究, 2013, 17(9): 1687-1694. DOI: 10.3969/j.issn.2095-4344.2013.09.025 |
| 作者姓名： | 张敏燕 王殊轶 严荣国 葛 斌 周 颖 |
| 作者单位： | 上海理工大学医疗器械与食品学院,上海市 200093 |
| 摘 要： | 背景：正电子发射计算机断层显像(PET)从分子水平反映细胞代谢和功能变化,MRI有更高的软组织对比度和空间分辨率,且无电磁辐射。近年来,随着多模式成像技术飞速发展,作为刚刚应用于临床的多模式分子成像技术,PET/MRI融合显像可提供分子、形态与功能信息,有关研究已成为分子影像领域的关注焦点。目的：就目前PET/MRI研制存在的问题和进展情况做一综述,并展望其潜在的临床和科研价值。方法：由第一作者应用计算机检索CNKI数据库、Springerlink数据库、Pubmed数据库相关文献。检索时间范围：2000年1月至2012年6月。英文检索词：“PET/MRI”和“multimodality imaging or image fusion”,中文检索词：“分子影像学”和“图像融合”。选择内容与PET/MRI多模式成像相关的文章,同一领域文献则选择近期发表或发表在权威杂志文章,共纳入53篇文献。结果与结论：已有的研究成果表明,PET/MRI较传统显像手段和其他成功的多模式成像技术,如PET/CT和SPECT/CT有更多、更新的应用优势,并已积累临床前和初步临床应用的经验,PET/MRI具有广阔的发展空间,有望将分子影像技术的发展带入一个新的时代,为临床诊断掀开新的篇章。 |
| 关 键 词： | 骨关节植入物 骨与关节植入物综述 PET MRI 多模式成像 分子影像 核医学 图像融合 图像配准 衰减校正 磁场兼容 功能影像 国家自然科学基金 |
| 收稿时间： | 2012-06-21 |
Positron emission tomography computed tomography/magnetic resonance imaging: A new progress of molecular imaging technique |
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| Zhang Min-yan,Wang Shu-yi,Yan Rong-guo,Ge Bin,Zhou Ying. Positron emission tomography computed tomography/magnetic resonance imaging: A new progress of molecular imaging technique[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(9): 1687-1694. DOI: 10.3969/j.issn.2095-4344.2013.09.025 | |
| Authors: | Zhang Min-yan Wang Shu-yi Yan Rong-guo Ge Bin Zhou Ying |
| Affiliation: | Department of Medical Devices and Food Sciences, University of Shanghai for Science & Technology, Shanghai 200093, China |
| Abstract: | BACKGROUND:Positron emission tomography can reflect the cell metabolism and functional changes of cells at the molecular level. Magnetic resonance imaging can obtain images with higher soft-tissue contrast and better spatial resolution without ionizing radiation. With the fast development of multimodality molecular imaging techniques, positron emission tomography/magnetic resonance imaging as a multimodality molecular imaging technique can provide the molecular, morphological and functional information, so its clinical application is an anticipating focus of medical molecular imaging.OBJECTIVE:To overview the progress and problems meet in the development of positron emission tomography/magnetic resonance imaging and to get a clear prospect of its potential clinical and scientific application.METHODS:The CNKI database, SpringerLink database and PubMed database were searched by the first author for the related articles from January 2000 to June 2012. The English key words were “PET/MRI” and “multimodality molecular imaging or image fusion”, and the Chinese key words were “molecular imaging” and “image fusion”. The articles related to positron emission tomography/magnetic resonance imaging multimodality molecular imaging technique were selected, and for the articles in the same field, those published recently or in the authorized journals were selected. A total of 53 articles were included.RESULTS AND CONCLUSION:From the existing research results, positron emission tomography/magnetic resonance imaging have more advantages over traditional and other multimodality imaging techniques such as positron emission tomography/computed tomography and single-photon emission computed tomography/ computed tomography, as demonstrated by the pre-clinical studies and preliminary clinical experiences, and have broader development space. So it has capacity to bring the development of molecular imaging technique and clinical diagnosis into a new area. |
| Keywords: | bone and joint implants review of bone and joint implants positron emission tomography magnetic resonance imaging multi-mode imaging molecular imaging nuclear medicine image fusion image registration attenuation correction magnetic field compatible functional imaging the Nationa Natural Science Foundation of China |
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