| 可溶性P-选择素和L-选择素在鼻息肉中的表达和意义 |
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| 引用本文： | 王欢,余宏. 可溶性P-选择素和L-选择素在鼻息肉中的表达和意义[J]. 中国耳鼻咽喉头颈外科, 2012, 19(4): 206-208 |
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| 作者姓名： | 王欢 余宏 |
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| 作者单位： | 云南省第二人民医院耳鼻喉科 |
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| 基金项目： | 2007年昆明医学院硕士研究生创新基金项目（KM2007L13） |
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| 摘 要： | 目的检测可溶性P-选择素和L-选择素在鼻息肉患者血清和组织匀浆中含量的变化,探讨其在鼻息肉发病机制中的作用及其与复发可能的相关性。方法采用酶联免疫吸附法和放射免疫法分别检测56例各型鼻息肉组及22例健康对照组的血清及组织匀浆中P-选择素和L-选择素的含量变化,做出分析。结果①两种方法测得P-选择素在实验组与对照组中的含量比较有统计学意义(P<0.05),伴有变应性鼻炎鼻息肉组、复发鼻息肉组与鼻窦炎鼻息肉组比较有统计学意义(P<0.05),伴有变应性鼻炎鼻息肉组、复发鼻息肉组比较无统计学意义(P>0.05)。②两种方法测得L-选择素在实验组与对照组中的含量比较有统计学意义(P<0.05),3组实验组组间两两比较无统计学意义(P>0.05)。结论高表达的P-选择素和L-选择素可能通过参与嗜酸细胞等炎症细胞的浸润、活化、增殖,从而在鼻息肉的形成过程中起重要作用。P-选择素表达量的多少可能与鼻息肉的复发有关。
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| 关 键 词： | 鼻息肉 P选择素 L选择素 嗜酸细胞 |
| 收稿时间： | 2011-10-25 |
Expression and significance of soluble P-selectin, L-selectin in nasal polyps |
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| WANG Huan,YU Hong. Expression and significance of soluble P-selectin, L-selectin in nasal polyps[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2012, 19(4): 206-208 |
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| Authors: | WANG Huan YU Hong |
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| Affiliation: | (Department of Otolaryngology,Yunnan No.2 People＇s Hospital,Kunming,Yunnan,650021,China) |
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| Abstract: | OBJECTIVE To detect the change of soluble P-selectin,L-selectin in serum and tissue homogenate of patients with nasal polyps,to investigate the pathogenesis and significance of P-selectin,L-selectin in nasal polyps.METHODS Changes of P-selectin,L-selectin in serum and tissue homogenate of 56 patients with nasal polyps and 22 cases of healthy control group were measured by enzyme linked immunosorbentassay and radio immunoassay.RESULTS ①The content of P-selectin have statistical significance（P0.05）between the experimental group and the control group;the content of P-selectin have statistical significance（P0.05）among three nasal polyp group;the content of p-selectin has no statistical significance（P0.05）in allergic rhinitis and nasal polyps group and nasal polyps recurrence group.②The content of L-selectin have statistical significance（P0.05）between the experimental group and the control group;the content of L-selectin showed no statistical significance（P0.05）among three nasal polyp group.CONCLUSION The high expression of P-selectin,L-selectin may participate in infiltration,activation,proliferation of eosinophilic and other infammatory cells which may play an important role in the formation of nasal polys.The expression of P-selectin may be related to recurrence of nasal polyps. |
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| Keywords: | Nanal Polyps P-Selectin L-Selectin Eosinophils |
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