|
|||||
|
|
| 通塞脉微丸活性成分的大鼠在体肠吸收研究 | |
| 引用本文： | 陈晓燕 狄留庆 赵晓莉 单进军 杨玲娟 朱蓉蓉 钱桂英. 通塞脉微丸活性成分的大鼠在体肠吸收研究[J]. 南京中医药大学学报, 2007, 23(4): 231-233 |
| 作者姓名： | 陈晓燕 狄留庆 赵晓莉 单进军 杨玲娟 朱蓉蓉 钱桂英 |
| 作者单位： | 南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029;南京中医药大学中医药研究院,江苏,南京,210029 |
| 基金项目： | 国家高技术研究发展计划(863计划) , 江苏省自然科学基金 |
| 摘 要： | 目的考察通塞脉微丸中的活性成分在大鼠不同肠段的吸收动力学及微丸与标准品的吸收差异，评价该制剂用药的合理性。方法采用大鼠在体小肠吸收实验方法。结果微丸中活性成分在小肠各部位均能较好地吸收，无特异性吸收部位。不同浓度溶液对甘草苷、阿魏酸和甘草酸铵的吸收无影响；浓度对肉桂酸吸收有差异，可能借助载体转运。结论标准品中甘草苷、甘草酸铵和肉桂酸较微丸吸收快，阿魏酸无显著差异，提示微丸维持药效更持久。 |
| 关 键 词： | 通塞脉微丸 活性成分 在体肠吸收 吸收速率常数 |
| 文章编号： | 1000-5005（2007）04-0231-03 |
| 收稿时间： | 2007-03-10 |
| 修稿时间： | 2007-03-102007-04-20 |
Rat In Vivo Study on Absorption of Active Components of Tongsaimai Micro-pellet |
|
| CHEN Xiao-yan,DI Liu-qing,ZHAO Xiao-li,SHAN Jin-jun,YANG Ling-juan,ZHU Rong-rong,QIAN Gui.yin. Rat In Vivo Study on Absorption of Active Components of Tongsaimai Micro-pellet[J]. Journal of Nanjing University of Traditional Chinese Medicine(Natural Science), 2007, 23(4): 231-233 | |
| Authors: | CHEN Xiao-yan DI Liu-qing ZHAO Xiao-li SHAN Jin-jun YANG Ling-juan ZHU Rong-rong QIAN Gui.yin |
| Affiliation: | Institute of Chinese Medicine and Pharmaology, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210029, china |
| Abstract: | OBJECTIVE To examine the absorption dynamics of the active components of Tongsaimai Micro-pellet at different portions of the intestine and the absorption differences between micro-pellet and the standard drug and evaluate the rationality of this preparation. METHOD In vivo experiment was used to observe the absorption in rat small intestine.RESULT The active components of Tongsaimai Micro - pellet were well absorbed at different portions of the intestine, with no specific absorption locations. Different concentrations of the solution did not affect the absorption of liquirtin, ferulaic acid and ammonium glycyrrhizinate, but affected the absorption of cinnamic acid. CONCLUSION The liquirtin, ammonium glycyrrhizinate and cinnamic acid in the standard drug are absorbed faster than those in the micro-pellet, but no marked differences were detected in the absorption of ferulaic acid, suggesting the enduring effect of micro-pellets. |
| Keywords: | Tongsaimai Micro-pellet active components in vivo intestine absorption absorption rate constant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《南京中医药大学学报》浏览原始摘要信息 | |
| 点击此处可从《南京中医药大学学报》下载全文 | |