| 氨氯地平和利培酮的1H和13C核磁共振信号归属 |
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| 引用本文： | 杨春晖,李勤,刘雪辉,赵兴凯,崔育新. 氨氯地平和利培酮的1H和13C核磁共振信号归属[J]. 中国药学, 2004, 13(1): 49-52 |
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| 作者姓名： | 杨春晖 李勤 刘雪辉 赵兴凯 崔育新 |
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| 作者单位： | [1]北京大学天然药物及仿生药物国家重点实验室 [2]北京天衡药物研究所，北京100071 |
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| 摘 要： | 目的对氨氯地平和利培酮两种药物分子进行核磁共振研究.方法应用一维和二维核磁共振技术,如gCOSY, gHSQC和gHMBC.结果对两种药物分子核磁共振氢谱和碳谱进行了归属,氟碳间的耦合常数对碳谱的解析提供了有利的证据.结论通过核磁共振化学位移和耦合常数的分析,确证了氨氯地平和利培酮两种药物分子的化学结构.
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| 关 键 词： | 核磁共振 归属 氟耦合常数 氨氯地平 利培酮 |
1H and 13C NMR Assignments for Amlodipine and Risperidone |
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| YANG Chun-hui,LI Qin,LIU Xue-hui,ZHAO Xing-kai,CUI Yu-Xin. 1H and 13C NMR Assignments for Amlodipine and Risperidone[J]. Journal of Chinese Pharmaceutical Sciences, 2004, 13(1): 49-52 |
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| Authors: | YANG Chun-hui LI Qin LIU Xue-hui ZHAO Xing-kai CUI Yu-Xin |
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| Abstract: | AimTo investigate the NMR spectroscopy of am lo dipine and risperidone. Methods1D NMR and 2D NMR experim ental techniques of gCOSY, gHSQC and gHMBC were wsed. ResultsThe assignments of the 1H and 13 C NMR data for the two drug s were performed and confirmed by the evidence of J HF and J CF . ConclusionThe structures of amlodipine and risperidone were confirmed by careful analysis of regular 1D and 2D NMR spectroscopy. |
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| Keywords: | NMR assignment fluorine coupling amlodipine risperidone |
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