CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines |
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| Authors: | Gwladys Zabouo Anne-Marie Imbert Jocelyne Jacquemier Pascal Finetti Thomas Moreau Benjamin Esterni Daniel Birnbaum François Bertucci Christian Chabannon |
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| Affiliation: | Gwladys Zabouo, Anne-Marie Imbert, Jocelyne Jacquemier, Pascal Finetti, Thomas Moreau, Benjamin Esterni, Daniel Birnbaum, François Bertucci, and Christian Chabannon |
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| Abstract: | Introduction Metastasis is a complex process involving loss of adhesion, migration, invasion and proliferation of cancer cells. Cell adhesion molecules play a pivotal role in this phenomenon by regulating cell–cell and cell–matrix interactions. CD146 (MCAM) is associated with an advanced tumor stage in melanoma, prostate cancer and ovarian cancer. Studies of CD146 expression and function in breast cancer remain scarce except for a report concluding that CD146 could act as a tumor suppressor in breast carcinogenesis. |
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