| 哺乳动物雷帕霉素靶蛋白复合物2靶向治疗肿瘤的研究进展 |
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| 引用本文： | 江克华,宋兴福. 哺乳动物雷帕霉素靶蛋白复合物2靶向治疗肿瘤的研究进展[J]. 中国肿瘤临床, 2011, 38(23): 1471-1474. DOI: 10.3969/j.issn.1000-8179.2011.23.014 |
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| 作者姓名： | 江克华 宋兴福 |
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| 作者单位： | 三峡大学第一临床医学院泌尿外科 (湖北省宜昌市443003) |
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| 摘 要： | 小分子抑制剂选择性的靶向杀伤肿瘤细胞，而对正常细胞无毒副作用，显示出很好的抗肿瘤前景。哺乳动物雷帕霉素靶蛋白复合物2（mTORC2）是一个非常有希望的靶点，最近研究发现mTORC2的活性在多种肿瘤的形成和侵袭中是必不可少的，而且mTORC2抑制剂靶向治疗肿瘤有着广泛的影响。本文就mTORC2的生物学特性及以mTORC2为靶点治疗肿瘤的前景进行综述。
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| 关 键 词： | 哺乳动物雷帕霉素靶蛋白复合物2 哺乳动物雷帕霉素靶蛋白 蛋白激酶B 雷帕霉素 |
Targeted Inhibition of mTORC2 in Treating Cancer |
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| Kehua JIANG,Xingfu SONG. Targeted Inhibition of mTORC2 in Treating Cancer[J]. Chinese Journal of Clinical Oncology, 2011, 38(23): 1471-1474. DOI: 10.3969/j.issn.1000-8179.2011.23.014 |
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| Authors: | Kehua JIANG Xingfu SONG |
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| Affiliation: | Targeted Inhibition of mTORC2 in Treating Cancer |
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| Abstract: | Small molecular inhibitors that selectively target cancer cells instead of normal cells are promising anti-cancer therapeutics. The mammalian target of rapamycin complex 2 ( mTORC2 ) is emerging as a potential target for inhibitors. Recent studies in oncobiology have indicated that the mTORC2 activity is essential for the transformation, as well as the vitality, of a number of cancer cell types, and that the mTORC2 inhibitor has a broad impact on cancer therapy. In the present study, new findings on the biology of mTORC2 signaling are summarized, and future prospects for mTOR-targeted therapy are highlighted. |
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