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| 盆腔舒胶囊对免疫功能影响及活血化瘀作用 | |
| 引用本文： | 张敦兰,金志春,谭宫屏,李辉,邵冬珊,熊富良. 盆腔舒胶囊对免疫功能影响及活血化瘀作用[J]. 医药导报, 2004, 23(4): 0222-0224 |
| 作者姓名： | 张敦兰 金志春 谭宫屏 李辉 邵冬珊 熊富良 |
| 作者单位： | 1. 湖北省妇女儿童医院妇产科,武汉,430070 2. 湖北省中医药研究院,武汉,430060 3. 武汉健民药业集团研究所,430050 |
| 摘 要： | 目的：通过盆腔舒胶囊对免疫功能及活血化瘀作用动物模型的研究，探讨盆腔舒胶囊治疗慢性盆腔炎的药效学基础。方法：对免疫功能的影响采用小鼠腹腔巨噬细胞吞噬功能、兔腹腔自身血凝块清除试验方法，对小鼠微循环的影响采用对小鼠肠系膜微循环毛细血管网交点数、细动脉流速及对血管流态的影响等方法。结果：盆腔舒胶囊能显著增强小鼠腹腔巨噬细胞吞噬功能，其作用优于妇科千金片，接近左旋咪唑；能促进兔腹腔血凝块的吸收与消散，其作用优于妇科千金片；对小鼠微循环的影响优于妇科千金片，接近山莨菪碱。结论：盆腔舒胶囊具有良好增强细胞免疫和体液免疫，改善微循环及活血化瘀等多种药理作用。 |
| 关 键 词： | 盆腔舒胶囊 免疫作用 活血化瘀 |
| 文章编号： | 1004-0781(2004)04-0222-03 |
| 修稿时间： | 2003-02-27 |
An Experimental Study of the Effect of Penqiangshu Capsules on the Immune Function and Microcirculation in Animals |
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| ZHANG Dun lan ,JIN Zhi chun ,TAN Gong ping ,LI Hui ,SHAO Dong shan ,XIONG Fu liang. An Experimental Study of the Effect of Penqiangshu Capsules on the Immune Function and Microcirculation in Animals[J]. Herald of Medicine, 2004, 23(4): 0222-0224 | |
| Authors: | ZHANG Dun lan JIN Zhi chun TAN Gong ping LI Hui SHAO Dong shan XIONG Fu liang |
| Affiliation: | ZHANG Dun lan 1,JIN Zhi chun 1,TAN Gong ping 2,LI Hui 1,SHAO Dong shan 2,XIONG Fu liang 3 |
| Abstract: | Objective:To probe into the basis of the pharmacodynamics of penqiangshu capsules in the treatment of chronic pelvic inflammation by observing the effect of the drug on the immune function and microcirculation in experimental animals. Methods:To appraise the influence of penqiangshu capsules on the immune function, their effects on the phagocytic function of peritoneal macrophage of the mouse, clearance of autologous blood clot in the abdominal cavity of the rabbit etc. were assayed. For the assessment of the influence of penqiangshu capsules on the microcirculation, their effects on the number of crossings in the capillary network of the mesenteric microcrculation, flow rate of blood in arteries in the mouse etc. were examined. Results: Penqiangshu capsules were shown to strikingly enhance the phagocytic function of macrophages from the abdominal cavity of the mouse, the effect being better than that of fukeqianjin tablets and close to that of levamisole. The drug was also shown to promote the absorption and clearance of autologous blood clot in the abdominal cavity of the rabbit, the effect being better than that of fukeqianjin tablets. These findings suggested that penqiangshu capsules had a fairly good effect of enhancing immune function. The effect of penqiangshu capsules in ameliorating microcirculation was shown to be better than that of fukeqianjin tablets and close to that of anisodamine. Conclusion: Penqiangshu capsules were shown to exert a series of pharmacological effects including enhancement of immunity, amelioration of microcirculation, activating blood flow and removing blood stasis. |
| Keywords: | Penqiangshu capsule Immunity Microcirculation |
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