| 变应性鼻炎鼻黏膜结构变化及微血管重塑实验研究 |
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| 引用本文： | 刘建国,刘月辉. 变应性鼻炎鼻黏膜结构变化及微血管重塑实验研究[J]. 中国耳鼻咽喉头颈外科, 2010, 17(1): 15-17 |
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| 作者姓名： | 刘建国 刘月辉 |
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| 作者单位： | 南昌大学第二附属医院耳鼻咽喉科,江西,南昌,330006;南昌大学第二附属医院耳鼻咽喉科,江西,南昌,330006 |
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| 基金项目： | 江西省自然科学基金资助课题(2007GZY1184);;江西省教育厅资助课题(Gjj08112);;江西省科技厅支撑计划(2009BSA10200)联合资助 |
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| 摘 要： | 目的探讨持续暴露变应原大鼠鼻黏膜结构及微血管的改变。方法60只SD大鼠随机分为正常对照组（A组）和持续暴露变应原组（B组）以卵清白蛋白激发法制备变应性鼻炎（allergic rhinitis,AR）模型,每组大鼠各半,采用鼻黏膜组织HE染色法和鼻黏膜微血管铸型方法分别观察8、12、16周鼻黏膜组织病理学特征和微血管形态学改变。结果与A组相比,B组大鼠的鼻黏膜变应原暴露8周后表现为黏膜上皮大量脱落,杯状细胞化生明显,腺体分泌旺盛;微血管铸形观察可见微血管扩张、通透性增加明显,行经迂曲。12,16周表现为上皮细胞剥脱明显,上皮下纤维化,杯状细胞化生减少,血管增生,血管内皮细胞轻度肿胀,毛细血管增生明显,管腔内壁不规则,管壁纤维化、增厚;微血管铸型观察可见血管内皮细胞肿胀甚至萎缩,管腔内壁不规则,管壁纤维化,毛细血管增生明显。结论AR鼻黏膜早期炎性损伤、后期黏膜组织增生和纤维修复及微循环血管重塑是持续暴露变应原AR大鼠鼻黏膜的组织病理学基础。
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| 关 键 词： | 变应原 鼻黏膜 增生 微血管铸型 |
| 收稿时间： | 2008-11-17 |
Allergic rhinitis nasal mucosa exposured to allergen histopathologic and the microvascular remodeling of SD rats |
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| LIU Jianguo,LIU Yuehui. Allergic rhinitis nasal mucosa exposured to allergen histopathologic and the microvascular remodeling of SD rats[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2010, 17(1): 15-17 |
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| Authors: | LIU Jianguo LIU Yuehui |
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| Affiliation: | Department of Otolaryngology;the Second Affiliated Hospital of Nanchang University;Nanchang;Jiangxi;330006;China |
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| Abstract: | OBJECTIVE To study the histopathologic and microvascular changes in allergic rhinitis nasal mucosa of SD rats following persistent exposure to allergen. METHODS A total of 60 heathy SD rats were divided into two groups randomly: the persistence group(n=30)and the control group(n=30). The animals of the persistence group were exposed to allergen persistently after modeling of 7 weeks with OVA provocation in nasal mucosa for 16 weeks. At 8, 12, 16 weeks after OVA provocation each group were sacrificed at each... |
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| Keywords: | Allergens Nasal Mucosa Hyperplasia microvascular corrosion cast |
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