Differential diffusions of indinavir and lopinavir in genital secretions of human immunodeficiency virus-infected women |
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| Authors: | Launay Odile Tod Michel Louchahi Kamel Belarbi Linda Bouchaud Olivier Mémain Nathalie Petitjean Olivier Robineau Michel Guillevin Loïc Lortholary Olivier |
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| Affiliation: | Fédération de Médecine Interne, Maladies Infectieuses et Tropicales and UPRES EA 3409, Université Paris-Nord, Bobigny, France. odile.launay@cch.ap-hop-paris.fr |
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| Abstract: | Plasma and cervicovaginal secretion (CVS) samples were collected from 19 human immunodeficiency virus type 1-infected women on lopinavir- or indinavir-containing regimens. Lopinavir and indinavir were detectable in 29 and 93% of CVS samples, respectively, a finding that may be ascribed to these drugs' differences in protein binding and pK(a). The relationship between lopinavir and indinavir pharmacodynamics and viral evolution in the female genital tract should be assessed over time. |
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