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| 腹腔筋膜室综合征对兔循环及呼吸功能的影响 | |
| 引用本文： | 陈煜,薛翔,王丽,金春华,邹衍泰. 腹腔筋膜室综合征对兔循环及呼吸功能的影响[J]. 南方医科大学学报, 2012, 32(9): 1312-1315 |
| 作者姓名： | 陈煜 薛翔 王丽 金春华 邹衍泰 |
| 作者单位： | 南方医科大学医学基础实验教学中心;南方医科大学南方医院肝胆外科 |
| 基金项目： | 广东省科技计划项目(2007B031511012) |
| 摘 要： | 摘要：目的制作家兔腹腔筋膜室综合征（ACS）模型，研究ACS对兔循环、呼吸功能及血液电解质水平的影响。方法将24只新 西兰兔平均分为4组，分别为对照组、ACS5组（IAP=5 mmHg）、ACS10组（IAP=10 mmHg）和ACS20组（IAP=20 mmHg），ACS模型 通过腹腔内出血（股动脉采血输入腹腔）合并腹腔内高压（注入不同量的氮气）实现，并在IAH后1 h观察兔血液动力学指标：左 心室收缩压（LVSP）、左心室舒张末期压（LVEDP）、左心室内压力最大变化速率（±dp/dt max）、动脉收缩血压（SP）、动脉舒张血压 （DP）、心率（HR）以及中心静脉压（CVP）；呼吸功能指标：呼吸频率（RR），动脉血氧分压（PaO2），动脉二氧化碳分压（PaCO2），动 脉血碳酸氢根[HCO3 -]；血液酸碱度及血K+浓度。结果ACS20组循环功能及呼吸功能指标与正常组相比有显著下降，且有酸中 毒及血钾升高（P均<0.05）；ACS10组循环功能指标及除RR及PaO2外的呼吸功能指标均有显著下降，但下降幅度小于ACS20组，且 同样有酸中毒及血钾升高（P均<0.05）；ACS5组除LVSP及HR有下降外（P<0.05），其余指标均无明显改变。结论腹内出血合并 腹内高压对兔循环、呼吸功能有一定损害并导致酸碱平衡及电解质紊乱，且可导致ACS发生。 |
| 关 键 词： | 腹腔内高压 腹腔筋膜室综合征 兔 心血管功能 呼吸功能 |
Effects of abdominal compartment syndrome on circulation and respiratory function in rabbits |
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| CHEN Yu,XUE Xiang,WANG Li,JIN Chunhua,ZOU Yantai. Effects of abdominal compartment syndrome on circulation and respiratory function in rabbits[J]. Journal of Southern Medical University, 2012, 32(9): 1312-1315 | |
| Authors: | CHEN Yu XUE Xiang WANG Li JIN Chunhua ZOU Yantai |
| Affiliation: | 2 Teaching Center of Experimental Medicine1,Department of Hepatobiliary Surgery,Nanfang Hospital2,Southern Medical University,Guangzhou 510515,China |
| Abstract: | Objective To establish a rabbit model of abdominal compartment syndrome(ACS) and evaluate the impact of ACS on cardiovascular and respiratory functions and blood electrolyte levels in rabbits.Methods Twenty-four New Zealand rabbits were randomly allocated into 4 equal groups,namely the normal control group,ACS5 group [intra-abdominal pressure(IAP)=5 mmHg],ACS10 group(IAP=10 mmHg) and ACS20 group(IAP=20 mmHg).ACS model was established by intra-abdominal bleeding(IAB) with intra-abdominal hypertension(IAH).All the data were recorded 1 h after inducing IAH including cardiovascular parameters(LVSP,LVEDP,±dp/dt max,SP,DP,HR,CVP),respiratory function(RR,PaO2,PaCO2,),blood pH,and electrolyte level().Results Compared with those in the normal control group,ACS20 group showed significantly decreased LVSP,LVEDP,±dp/dt max,SP,DP,HR,RR,PaO2,,and blood pH but increased CVP,PaCO2,and K+(P<0.05).In ACS10 group,all the parameters except for RR and PaO2 showed similar changes as seen in ACS20 group(P<0.05) but with lower amplitudes of variations.In ACS5 group,only LVSP and HR were reduced remarkably(P<0.05) while the other parameters showed no significant variations.Conclusion IAB plus IAH may cause damage to the cardiovascular and respiratory functions and lead to ACS in rabbits. |
| Keywords: | intra-abdominal hypertension abdominal compartment syndrome rabbit cardiovascular function respiratory function |
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