| 清醒大鼠肺功能检测系统在全氟异丁烯吸入毒理研究中的应用 |
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| 引用本文： | 孙晓红,张宪成,黄春倩,孟革,付荦援,赵建,苏瑞斌. 清醒大鼠肺功能检测系统在全氟异丁烯吸入毒理研究中的应用[J]. 国际药学研究杂志, 2011, 38(6): 445-447,461 |
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| 作者姓名： | 孙晓红 张宪成 黄春倩 孟革 付荦援 赵建 苏瑞斌 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金，国家"重大新药创制"科技重大专项 |
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| 摘 要： | 目的 考察在全氟异丁烯(PFIB)吸入毒理实验中引进清醒动物肺功能检测系统是否有助于PFIB中毒的诊断和治疗.方法 利用清醒动物肺功能检测系统,检测PFIB吸入中毒大鼠中毒前后不同时间的呼吸功能指标(吸气时间、呼气时间、呼吸频率、吸气流量峰值、呼气流量峰值、潮气量和呼气量).结果 Wistar大鼠给予PFIB 150 ...
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| 关 键 词： | 肺功能检测系统 全氟异丁烯 吸入毒理 大鼠 |
| 收稿时间： | 2011-10-19 |
| 修稿时间： | 2011-11-04 |
Application of pulmonary function test system in the study of perfluoroisobutylene inhalation toxicology |
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| SUN Xiao-hong,ZHANG Xian-cheng,HUANG Chun-qian,MENG Ge,FU Luo-yuan,ZHAO Jian,SU Rui-bin. Application of pulmonary function test system in the study of perfluoroisobutylene inhalation toxicology[J]. Foreign Medical Sciences(Section of Pharmarcy), 2011, 38(6): 445-447,461 |
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| Authors: | SUN Xiao-hong ZHANG Xian-cheng HUANG Chun-qian MENG Ge FU Luo-yuan ZHAO Jian SU Rui-bin |
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| Affiliation: | (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China) |
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| Abstract: | Objective To measure if the pulmonary function test system of unrestrained animals could help diagnosis and treatment of perfluoroisobutylene (PFIB) inhalation toxicosis. Methods To record the change in pulmonary function parameters, such as inspiratory time (TI) , expiratory time (TE) , breathing frequency (F) , peak inspiratory flow (PIF) , peak expiratory flow (PEF) , tidal volume (VT) and expired volume (VE) , by unrestrained whole body plethysmography (EMKA Technologies, France) , before and after Wistar rats exposed to 150 mg/m3 PFIB for 8 min. Results The TI and TE decreased obviously at 4 h after PFIB exposure, and reduced to 129 ms and 215 ms at 8 h after PFIB exposure, respectively. The PIF, PEF and the breathing frequency increased significantly, on the contrary, the VT and VE decreased markedly at 8 h after PFIB exposure. Conclusion The pulmonary function test system can be handled easily, and can be used for measuring the changes in pulmonary parameters in the study of inhalation toxicology. |
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| Keywords: | pulmonary function test system perfluoroisobutylene inhalation toxicology rat |
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