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Aztreonam penetration into synovial fluid and bone. |
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| Authors: | C M MacLeod E A Bartley J O Galante L T Friedhoff R Dhruv |
| Abstract: | Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum. |
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