| 贫血与认知障碍关系的meta分析 |
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| 引用本文： | 雷梦媛1,李俊晴1,杨艳艳1,王娜2,杨梦竹2,吕琳2,李博1. 贫血与认知障碍关系的meta分析[J]. 现代预防医学, 2021, 0(4): 754-758 |
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| 作者姓名： | 雷梦媛1 李俊晴1 杨艳艳1 王娜2 杨梦竹2 吕琳2 李博1 |
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| 作者单位： | 1. 河南大学慢性病风险评价研究所，河南 开封 475004；2. 河南大学护理与健康学院 |
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| 摘 要： | 目的 系统评价贫血与认知障碍之间的关系，为认知障碍的预防提供循证支持。方法 计算机全面检索PubMed、The Cochrane Library、EMbase、万方数据库(WangFang Data)、中国知网(CNKI)和维普(VIP)数据库中关于贫血与认知障碍风险的队列研究，时限均自建库至2020年8月14日。对最终纳入的文献进行数据提取与质量评价，所得数据采用Stata 14.0软件进行meta分析。结果 最终纳入10篇文献，共计4 701个患者。纳入文献均为中高等质量水平。meta分析结果显示:贫血将增加认知障碍风险的可能性（OR = 1.36，95%CI:1.23～1.49，P＜0.01），且差异有统计学意义。亚组分析结果显示与整体结果基本一致。结论 当前证据表明，贫血人群患认知障碍风险要高于正常人群，但受纳入研究和样本量限制，上述结论需要更多高质量研究予以验证。
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| 关 键 词： | 贫血 认知障碍 痴呆 阿尔茨海默症 meta分析 队列研究 |
Meta-analysis of anemia and risk of cognitive impairment |
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| LEI Meng-yuan,LI Jun-qing,YANG Yan-yan,WANG Na,YANG Meng-zhu,LV Lin,LI Bo. Meta-analysis of anemia and risk of cognitive impairment[J]. Modern Preventive Medicine, 2021, 0(4): 754-758 |
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| Authors: | LEI Meng-yuan LI Jun-qing YANG Yan-yan WANG Na YANG Meng-zhu LV Lin LI Bo |
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| Affiliation: | Institute of Chronic Disease Risk Evaluation, Henan University, Kaifeng, Henan 475004, China |
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| Abstract: | To systematically evaluate the relationship between anemia and cognitive impairment, providing evidence-based support for the prevention of cognitive impairment. Methods The Cochrane Library, EMbase, WangFang Data, CNKI and VIP databases were searched for cohort studies on the relationship between anemia and cognitive impairment up to August 14, 2020. Data extraction and quality evaluation of the final included literature were carried out, and meta-analysis was performed using Stata 14.0 software. Results A total of 10 articles were included involving 4 701 patients. The included literatures were all medium quality or above. The meta-analysis results showed that anemia could increase the possibility of cognitive impairment, with an OR value of 1.36(95%CI: 1.23-1.49, P<0.01). The results of subgroup analysis showed general agreement with the overall results. Conclusion Current evidence shows that the risk of cognitive impairment in people with anemia is higher than that in normal people. Due to the limitations of included studies and sample size, the conclusion needs to be verified by more high-quality studies. |
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| Keywords: | Anemia Cognitive Impairment Dementia Alzheimer’s Disease Meta-Analysis Cohort Study |
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