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Recombinant human gamma interferon inhibits simian malaria. |
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| Authors: | R K Maheshwari C W Czarniecki G P Dutta S K Puri B N Dhawan R M Friedman |
| Abstract: | Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development. |
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