| 恶性疟原虫var基因家族与抗原变异研究进展 |
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| 引用本文： | 方小楠. 恶性疟原虫var基因家族与抗原变异研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2010, 28(2): 153-156 |
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| 作者姓名： | 方小楠 |
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| 作者单位： | 同济大学医学院病原生物学与免疫学系，上海 200092 |
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| 基金项目： | 上海市卫生局科研项目(No.2008Y025)~~ |
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| 摘 要： | 恶性疟原虫变异抗原基因(var基因)家族编码的恶性疟原虫红细胞膜蛋白1(PfEMP1)是介导恶性疟原虫抗原变异和红细胞黏附微血管的媒介。本文从恶性疟原虫抗原变异和致病性、感染红细胞表面变异分子的表达、var基因家族的基因结构、PfEMP1蛋白的黏附特性以及var基因家族的变异调控等方面对恶性疟原虫var基因家族与抗原变异的研究进行综述。
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| 关 键 词： | 恶性疟原虫；变异抗原基因；恶性疟原虫红细胞膜蛋白1；抗原变异 |
Var Gene Family and Antigen Variation in Plasmodium falciparum |
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| FANG Xiao-nan. Var Gene Family and Antigen Variation in Plasmodium falciparum[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2010, 28(2): 153-156 |
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| Authors: | FANG Xiao-nan |
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| Affiliation: | FANG Xiao-nan(Department of Pathogenic Biology , Immunology,School of Medicine,Tongji University,Shanghai 200092,China) |
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| Abstract: | An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte membrane protein 1(PfEMP1), encoded by var genes, is responsible for both antigenic variation and cytoadhesion of infected erythrocytes at microvasculature sites throughout the body. The article summarizes antigen variation and pathogenicity, variation molecules expressed on infected erythrocytes, structure of var gene family, PfEMP1 adhesion properites, and regulation of variation in Plasmodium falciparum var gene family. |
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| Keywords: | Plasmodium falciparum Var gene PfEMP1 Antigen variation |
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