| 国产与进口药物洗脱支架治疗前降支开口病变的临床疗效比较 |
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| 引用本文： | 李东宝,华琦,刘志,李静,许立庆,王珊,金尉英. 国产与进口药物洗脱支架治疗前降支开口病变的临床疗效比较[J]. 心脏杂志, 2010, 22(4): 556-559 |
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| 作者姓名： | 李东宝 华琦 刘志 李静 许立庆 王珊 金尉英 |
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| 作者单位： | 首都医科大学宣武医院心脏科，北京 100053 |
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| 摘 要： | 目的:比较国产与进口药物洗脱支架治疗前降支开口病变的临床疗效。方法:回顾性分析95例前降支开口病变的患者置入国产支架(国产支架组,n=68)和进口支架(进口支架组,n=27),所有患者均行临床随访,部分患者进行了冠状动脉造影(CAG)复查。结果:国产支架组的急性心肌梗死患者多于进口支架组,但无统计学差异(46%vs.33%)。两组的介入成功率均为100%。国产支架组的冠脉钙化率、偏心斑块率和C型病变率均高于进口支架组(分别为20%vs.4%;14%vs.0%;28%vs.7%,均P0.05)。两组CAG随访的支架内和血管段再狭窄率无统计学差异;两组的主要不良事件发生率也无统计学差异。结论:国产药物洗脱支架治疗前降支开口病变是安全的,与进口药物洗脱支架具有相似的良好疗效。
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| 关 键 词： | 药物洗脱支架 左前降支开口病变 经皮冠状动脉脉介入治疗 |
| 收稿时间： | 2009-03-28 |
Comparison of the efficacy between Chinese-made and USA-made drug-eluting stents in treatment of ostial lesions of the left anterior descending coronary artery |
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| Abstract: | AIM: To compare the efficacy of Chinese-made and USA-made sirolimus-eluting stents in the treatment of ostial lesion of the left anterior descending (LAD) coronary artery. METHODS: Ninety-five patients with LAD ostial lesion were implanted with stents made in China (Chinese-made stent group, n=68) or stents made in the USA (USA-made stent group, n=27). Follow-ups were conducted in all patients and angiographic examinations were performed in some patients. RESULTS: The procedure was successful in all patients. More acute myocardial infarction was observed in Chinese-made stent group but no significant difference was found between groups (46% vs. 33%, P=0.31). Significantly more calcified, eccentric plaques and C-type lesions were seen in the Chinese-made stent group compared with those seen in the USA-made stent group (20% vs. 4%; 14% vs. 0%; 28% vs. 7%, P<0.05), but angiographic follow-up showed no significant difference in the rate of in-stent and in-segment restenosis between groups. No significance was observed in the rate of main adverse events between groups. CONCLUSION: Compared with USA-made sirolimus-eluting stents, Chinese-made sirolimus-eluting stents are as safe and effective in the treatment of LAD coronary artery ostial lesion. |
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