Lifetime risk of end‐stage kidney disease in living donors for paediatric kidney transplant recipients in Australia and New Zealand – a retrospective study |
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| Authors: | Darren Lee John B. Whitlam Natasha Cook Amanda M. Walker Matthew A. Roberts Francesco L. Ierino Joshua Y. Kausman |
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| Affiliation: | 1. Department of Renal Medicine, Eastern Health, Box Hill, Vic., Australia;2. Eastern Health Clinical School, Monash University, Clayton, Vic., Australia;3. Department of Nephrology, Austin Health, Heidelberg, Vic., Australia;4. University of Melbourne, Parkville, Vic., Australia;5. Department of Nephrology, Royal Children's Hospital, Parkville, Vic., Australia;6. Murdoch Children's Research Institute, Parkville, Vic., Australia;7. Department of Nephrology, St Vincent's Hospital Melbourne, Fitzroy, Vic., Australia |
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| Abstract: | Living kidney donors (LKD) for paediatric kidney transplant recipients (KTR) have a heightened motivation to donate for emotional reasons and the clear health benefits to the KTR. We hypothesized that the cohort of LKD for paediatric KTR (LKD‐P) includes motivated young parents with a higher lifetime end‐stage kidney disease (ESKD) risk compared to adult KTR (LKD‐A). Data from the Australia and New Zealand Dialysis and Transplant LKD Registry (2004–2015) was analysed to compare baseline characteristics and predonation ESKD risk in LKD‐P (n = 315) versus LKD‐A (n = 3448). LKD‐P were younger (median age 42 vs. 50 years; P < 0.001) and had a marginally higher lifetime ESKD risk (median 0.44% vs. 0.40%; P < 0.01), with a similar proportion of LKD exceeding 1% risk threshold (5.4% vs. 5.6%; P = NS). Compared to grandparents as LKD‐P, parents (median age 41 vs. 59 years; P < 0.001) had a higher lifetime ESKD (0.44% vs. 0.25%; P < 0.001). Although unique benefits to paediatric KTR justify the minor increase in lifetime ESKD risk in young parents, carefully selected grandparents are an alternative LKD‐P option, allowing parents to donate for subsequent transplants. |
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| Keywords: | living donors paediatric kidney transplantation |
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