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beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats. |
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| Authors: | Y Hosobuchi M Meglio J E Adams C H Li |
| Abstract: | Tolerance to beta-endorphin developed acutely in cats if the administration of the peptide was repeated within the first 24 hr. The tolerance was reversed immediately by systemic administration of the serotonin precursor, 5-hydroxytryptophan. It was further shown that 5-hydroxytryptophan potentiates the analgesic effect of the subliminal dose of beta-endorphin. |
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