The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation. |
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| Authors: | M D Tabone K Muanza M Lyagoubi C Jardel S Pied O Amedee-Manesme G E Grau D Mazier |
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| Affiliation: | INSERM U 313, Hôpital de la Salpétrière, Paris, France. |
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| Abstract: | Kinetics of serum levels of interleukin-6 (IL-6) were studied in patients with acute Plasmodium falciparum malaria in relation to vitamin A and its binding proteins, retinol binding protein (RBP) and pre-albumin. It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. These data suggest that vitamin A supplementation alone might still be insufficient to restore a malaria-induced vitamin A deficiency. |
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