Treatment of murine disseminated candidiasis with L-743,872. |
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| Authors: | J R Graybill L K Najvar M F Luther A W Fothergill |
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| Abstract: | L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis. |
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