| 大蒜新素对实验性急性脑缺血的保护作用 |
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| 引用本文： | 马晓红,刘天培. 大蒜新素对实验性急性脑缺血的保护作用[J]. 中国药理学与毒理学杂志, 1998, 12(2): 151-152 |
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| 作者姓名： | 马晓红 刘天培 |
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| 作者单位： | 南京医科大学药理学教研室 |
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| 摘 要： | 大蒜新素对实验性急性脑缺血的保护作用马晓红１刘天培（南京医科大学药理学教研室，南京２１００２９）大蒜新素（ａｌｉｔｒｉｄｉ，Ａｌ）为葱科植物大蒜中的有效成分，已发现其有降压，降血脂，抗动脉粥样硬化，抗血小板聚集及抗心肌缺血等作用［１，２］．临床上有关...
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| 关 键 词： | 大蒜新素； 脑缺血； 超氧化物歧化酶； 丙二醛 |
| 收稿时间： | 1996-11-18 |
Protective effect of allitridi on the experimental acute cerebral ischemia |
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| MA Xiao-Hong, LIU Tian-Pei. Protective effect of allitridi on the experimental acute cerebral ischemia[J]. Chinese Journal of Pharmacology and Toxicology, 1998, 12(2): 151-152 |
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| Authors: | MA Xiao-Hong LIU Tian-Pei |
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| Affiliation: | (Department of Pharmacology, Nanjing Medical University, Nanjing 210029) |
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| Abstract: | The protective effect of allitridi at different dosage(1.5, 3.0, 6.0 mg·kg-1 iv 10 min before ischemia) on acute experimental cerebral ischemia was studied. Acute cerebral ischemia caused an inhibited activity of superoxide dismutase and an increased content of malondialdehyde in cortexes of mice and in cortexes and hippocampus of rats. Allitridi increased the survival time in the cerebral ischemic mice induced by ligating both common carotid arteries and both vagus nerves from 2.5±1.0 (control) to 9±14, 15±5 and 26±13 min. These results suggest that allitridi have a protective effect on the acute cerebral ischemia. The anti-oxygen free radical action of allitridi may contribute to its protective effect on the cerebral ischemic injury. |
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| Keywords: | allitridi cerebral ischemia superoxide dismutase malondialdehyde |
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