| 内皮微粒与急性心肌梗死严重程度和预后的相关性 |
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| 引用本文： | 张欣,周静,张宗棨. 内皮微粒与急性心肌梗死严重程度和预后的相关性[J]. 心脏杂志, 2019, 31(3): 274-277. DOI: 10.12125/j.chj.201901037 |
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| 作者姓名： | 张欣 周静 张宗棨 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院心血管内科，上海 201900 |
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| 基金项目： | 国家自然科学基金青年科学基金项目资助资助（81200206） |
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| 摘 要： | 目的 探讨内皮微粒(EMP)与急性心肌梗死(AMI)严重程度及预后之间的相关性。方法 入组AMI患者90例,根据Gensini积分分为2组:轻度病变组(n=48)和严重病变组(n=42)。对AMI患者随访一年,根据预后情况分为2组:预后良好组(n=23)和预后不良组(发生不良心血管事件者,n=67)。流式微球技术检测血浆EMP,分析EMP与冠脉病变严重程度及预后的相关性。结果 冠脉病变程度不同的两组间EMP、左室射血分数(LVEF)、无复流发生比例均有显著差别;EMP、无复流、LVEF是与冠脉病变严重程度相关的独立因素;对AMI患者随访1年左右,发现预后不良组LVEF值更低、EMP值更高、Genesini积分更高、3支病变及无复流现象更常见,3支病变、EMP、Gensini积分、LVEF、无复流是AMI预后不良的独立相关因素。结论 EMP在评价AMI冠脉严重程度、冠脉血流恢复情况及预测患者预后方面具有一定的临床意义。
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| 关 键 词： | 内皮微粒 急性心肌梗死 左室射血分数 预后 |
| 收稿时间： | 2019-01-28 |
Correlation of endothelial microparticles and severity and prognosis of acute myocardial infarction |
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| ZHANG Xin,ZHOU Jing,ZHANG Zong-. Correlation of endothelial microparticles and severity and prognosis of acute myocardial infarction[J]. Chinese Heart Journal, 2019, 31(3): 274-277. DOI: 10.12125/j.chj.201901037 |
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| Authors: | ZHANG Xin ZHOU Jing ZHANG Zong- |
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| Affiliation: | Department of Cardiology, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201900, China |
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| Abstract: | AIM To study the role of endothelial microparticles (EMP) in evaluating acute myocardial infarction (AMI) lesion severity and predicting AMI prognosis. METHODS 90 AMI patients were divided into two groups according to GENESI scores: a mild coronary artery disease group (n = 48) and a severe lesion group (n=48). The patients were followed up for about 1 year and they were divided into two groups according to their prognosis: a group with good prognosis (n = 23) and a group with poor prognosis (with adverse cardiovascular events, n = 67). Plasma EMP levels (EMP defined as CD31+/CD146+) were detected using flow cytometry and the correlation between EMP and the severity and prognosis of coronary artery disease was analyzed using SPSS 17.0. RESULTS Significant differences in EMP levels, LVEF (left ventricular ejection fraction), and rate of no-reflow were found between the two groups. EMP, no reflow, and LVEF were independent factors related to the severity of coronary artery lesions. The follow-up for prognosis of AMI patients found lower LVEF, higher EMP values, high GENESI scores, more incidence of three-vessel lesions, and no-reflow in the group with unfavorable prognosis. Three-vessel lesions, EMP, GENESI scores and no-reflow were independent factors correlated with poor prognosis of AMI. CONCLUSION Plasma EMP levels can be used in AMI patients for evaluating the severity of coronary heart disease lesions and reperfusion condition, and for predicting long-term prognosis of AMI. |
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| Keywords: | endothelial microparticles acute myocardial infarction left ventricular ejection fraction prognosis |
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