| 甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的疗效及对炎症因子的影响 |
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| 引用本文： | 汪珊,韦红,李启先. 甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的疗效及对炎症因子的影响[J]. 蚌埠医学院学报, 2022, 47(1): 44-46. DOI: 10.13898/j.cnki.issn.1000-2200.2022.01.011 |
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| 作者姓名： | 汪珊 韦红 李启先 |
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| 作者单位： | 安徽医科大学附属六安市人民医院 儿科, 安徽 六安 237005 |
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| 基金项目： | 国家卫生计生委医药卫生科技发展研究项目w2016EWAH15 |
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| 摘 要： | 目的:探讨甲泼尼龙琥珀酸钠对比常规对症治疗儿童重症支原体肺炎的疗效及对炎性因子的影响.方法:选择重症支原体肺炎患儿60例,采用随机数字表法将病人分为研究组与对照组,各30例.对照组采用常规对症治疗,研究组在对照组基础上结合甲泼尼龙琥珀酸钠治疗.比较2组临床症状改善情况,治疗前后血清中白细胞介素-6(IL-6)、肿瘤坏死...
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| 关 键 词： | 重症支原体肺炎 甲泼尼龙琥珀酸钠 炎性因子 儿童 |
| 收稿时间： | 2019-11-21 |
Effect of methylprednisolone sodium succinate in the treatment of severe mycoplasma pneumonia in children and its effects on inflammatory factors |
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| WANG Shan,WEI Hong,LI Qi-xian. Effect of methylprednisolone sodium succinate in the treatment of severe mycoplasma pneumonia in children and its effects on inflammatory factors[J]. Journal of Bengbu Medical College, 2022, 47(1): 44-46. DOI: 10.13898/j.cnki.issn.1000-2200.2022.01.011 |
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| Authors: | WANG Shan WEI Hong LI Qi-xian |
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| Affiliation: | Department of Pediatrics, Lu'an People's Hospital Affiliated to Anhui Medical University, Lu'an Anhui 237005, China |
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| Abstract: | ObjectiveTo investigate the effects of methylprednisolone sodium succinate in the treatment of severe mycoplasma pneumonia, and its influence on inflammatory factors in children.MethodsSixty children with severe mycoplasma pneumonia were divided into the study group and control group according to the random umber table method(50 cases in each group).The control group was treated with conventional symptomatic treatment, while the study group was treated with methylprednisolone sodium succinate on the basis of the control group.The clinical symptoms improvement, and serum levels of interleukin-6(IL-6), tumor necrosis factor α(TNF-α), interferon γ(IFN-γ) and C-reactive protein(CRP) before and after treatment were compared between two groups.ResultsThe time of fever abatement, cough disappearance and lung rales disappearance in study group were significantly shorter than those in control group(P < 0.01).Before treatment, there was no statistical significance in the levels of CRP, IL-6, TNF-α and IFN-γ between two groups(P>0.05).After treatment, the levels of CRP, IL-6, TNF-α and IFN-γ in two groups were lower than those before treatment(P < 0.05), and the levels of CRP, IL-6, TNF-α and IFN-γ in study group were lower than those in control group(P < 0.05 to P < 0.01).ConclusionsOn the basis of routine symptomatic treatment, the adjuvant therapy of methylprednisolone sodium succinate can effectively improve the clinical symptoms, promote the decline of inflammatory factors, reduce the inflammatory response, and has significant effects in children with severe mycoplasma pneumonia. |
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