| 子宫内膜异位症病人炎症因子和凝血因子的水平变化及临床意义 |
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| 引用本文： | 阳桂芬,邓文. 子宫内膜异位症病人炎症因子和凝血因子的水平变化及临床意义[J]. 蚌埠医学院学报, 2022, 47(2): 212-214, 218. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.019 |
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| 作者姓名： | 阳桂芬 邓文 |
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| 作者单位： | 中国人民解放军联勤保障部队第九二四医院 妇科, 广西 桂林 541001 |
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| 摘 要： | 目的检测子宫内膜异位症（内异症）病人外周血中炎症因子和凝血因子的水平，进一步探讨炎症因子和凝血因子在内异症中的作用及临床诊断价值。方法选取经手术后确诊为Ⅲ期、Ⅳ期内异症的病人216例（内异症组），和病理学检测确诊为良性囊肿的病人117例（对照组）。比较2组病人的一般临床资料、外周血中炎症因子、凝血因子和癌抗原125（CA125）的水平。比较不同分期病人间的炎症因子和凝血因子的水平。受试者工作特征曲线评估CA125、纤维蛋白原水平（FIB）单独及联合检测对Ⅲ期、Ⅳ期内异症病人的诊断价值。结果内异症组孕次和产次均多于对照组（P < 0.01）。内异症组中性粒细胞淋巴细胞比值（NLR）、血小板淋巴细胞比值（PLR）、D-二聚体（D-D）、C-反应蛋白（CRP）和红细胞沉降率均高于对照组，内异症组凝血酶原时间（PT）和凝血酶时间（TT）时间均短于对照组，FIB和CA125水平均高于对照组，差异均有统计学意义（P < 0.01）。Ⅳ期内异症组与Ⅲ期内异症组比较，血小板和PLR水平较高，PT时间较短，FIB较高，差异均有统计学意义（P < 0.05~P < 0.01），2组NLR和D-D、活化部分凝血酶原时间和TT的水平差异均无统计学差异（P>0.05）。CA125联合FIB检测诊断内异症的灵敏度为84.6%，CA125单独检测的灵敏度为81.9%，FIB单独检测的灵敏度为50.4%。结论炎症因子和凝血因子在内异症组中表达异常，且与内异症的分期相关，CA125和FIB的联合检测可提高诊断内异症的灵敏度。
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| 关 键 词： | 子宫内膜异位症 炎症因子 凝血因子 癌抗原125 纤维蛋白原 |
| 收稿时间： | 2020-04-08 |
Changes and clinical significance of the levels of inflammatory factors and coagulation factors in patients with endometriosis |
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| YANG Gui-fen,DENG Wen. Changes and clinical significance of the levels of inflammatory factors and coagulation factors in patients with endometriosis[J]. Journal of Bengbu Medical College, 2022, 47(2): 212-214, 218. DOI: 10.13898/j.cnki.issn.1000-2200.2022.02.019 |
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| Authors: | YANG Gui-fen DENG Wen |
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| Affiliation: | Department of Gynecology, The 924th Hospital of PLA Joint Logistic Support Force, Guilin Guangxi 541001, China |
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| Abstract: | ObjectiveTo detect the levels of inflammatory factors and coagulation factors in peripheral blood of patients with endometriosis, and further explore the role of inflammatory factors and coagulation factors in endometriosis and its clinical diagnostic value.MethodsA total of 216 patients diagnosed as stage Ⅲ and Ⅳ endometriosis after surgery and 117 patients with benign cysts diagnosed by pathology were divided into the endometriosis group and control group, respectively.The general clinical data, levels of inflammatory factors, coagulation factors and cancer antigen 125(CA125) in peripheral blood were compared between two groups.The levels of inflammatory and coagulation factors were compared among patients of different stages.The ROC curve was used to evaluate the diagnostic value of CA125 and fibrinogen level(FIB) alone or combined in patients with stage Ⅲ and Ⅳ.ResultsThe number of pregnancies and births in endometriosis group were higher than those in control group(P < 0.01).The neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR), D-dimer(D-D), C-reactive protein(CRP) and erythrocyte sedimentation rate in endometriosis group were higher than those in control group(P < 0.01).The prothrombin time(PT) and thrombin time(TT) in endometriosis group were shorter than those in control group(P < 0.01), and the levels of FIB and CA125 levels in endometriosis group were higher than those in control group(P < 0.01).Compared with stage Ⅲ group, the levels of PLT and PLR were higher, the PT time was shorter, and the FIB was higher in stage Ⅳ group(P < 0.05 to P < 0.01).The differences of the levels of NLR and D-D, APTT and TT between stage Ⅲ group and stage Ⅳ group were not statistically significant(P>0.05).In the diagnosis of endometriosis, the sensitivity of CA125 combined with FIB was 84.6%, the sensitivity of CA125 was 81.9%, the sensitivity of FIB was 50.4%.ConclusionsThe expression of inflammatory and coagulation factors is abnormal in the endometriosis group, and which is correlated with the stage of endometriosis.The combined detection of CA125 and FIB can improve the sensitivity of the diagnosis of endometriosis. |
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