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Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small‐cell carcinoma of the ovary,hypercalcaemic type distinguishes these tumours from their mimics
Authors:Blaise A Clarke  Leora Witkowski  Tuyet N Ton Nu  Patricia A Shaw  C Blake Gilks  David Huntsman  Anthony N Karnezis  Neil Sebire  Janez Lamovec  Lawrence M Roth  Colin J R Stewart  Martin Hasselblatt  William D Foulkes  W Glenn McCluggage
Affiliation:1. Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, ON, Canada;2. Toronto General Hospital, Toronto, ON, Canada;3. Department of Human Genetics, McGill University, Montreal, QC, Canada;4. Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada;5. Department of Pathology, McGill University Health Centre, Montreal, QC, Canada;6. Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada;7. Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, BC, Canada;8. Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada;9. Department of Histopathology, Great Ormond Street Hospital, London, UK;10. Institute of Child Health, University College London, London, UK;11. Department of Pathology, Institute of Oncology, Ljubljana, Slovenia;12. Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA;13. School for Women's and Infants' Health, University of Western Australia, Perth, WA, Australia;14. KEMH, Perth, WA, Australia;15. Institute of Neuropathology, University Hospital Münster, Münster, Germany;16. Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, QC, Canada;17. Department of Pathology, Belfast Health and Social Care Trust, Royal Group of Hospitals Trust, Royal Group of Hospitals, Belfast, UK
Abstract:
Keywords:differential diagnosis  immunohistochemistry  ovary  small‐cell carcinoma of ovary (hypercalcaemic type)  SMARCA4  SMARCB1
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