Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients |
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| Authors: | Andrés María T Viejo-Diaz Mónica Pérez Francisco Fierro José F |
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| Affiliation: | Laboratory of Oral Microbiology, School of Stomatology, University of Oviedo, Oviedo, Spain. |
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| Abstract: | Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (< or = 6-fold) than other clinical strains. |
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