Mutations in katG,inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis |
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| Authors: | Silva Márcia Susana N Senna Simone G Ribeiro Marta O Valim Andréia R M Telles Maria Alice Kritski Afrânio Morlock Glenn P Cooksey Robert C Zaha Arnaldo Rossetti Maria Lucia R |
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| Affiliation: | Márcia Susana N. Silva, Simone G. Senna, Marta O. Ribeiro, Andréia R. M. Valim, Maria Alice Telles, AfrÂnio Kritski, Glenn P. Morlock, Robert C. Cooksey, Arnaldo Zaha, and Maria Lucia R. Rossetti |
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| Abstract: | The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states. Point mutations in codon 315 of the katG gene were observed in 87.1, 60.9, and 60% of the isolates from Rio Grande do Sul, Rio de Janeiro, and S?o Paulo, respectively. Mutations in the inhA gene were identified only in one isolate from RJ State, and the ahpC promoter region revealed mutations in distinct positions in 12.9, 21.7, and 6.7% of the isolates from RS, RJ and SP, respectively. |
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