| 前列腺癌患者治疗及生活质量调查——基于网络问卷的真实世界研究 |
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| 引用本文： | 李洪振,亓昕,高献书,秦尚彬,马茗微,张敏,王庆国,李晓颖,白赟. 前列腺癌患者治疗及生活质量调查——基于网络问卷的真实世界研究[J]. 中华临床医师杂志(电子版), 2018, 12(2): 80-84. DOI: 10.3877/cma.j.issn.1674-0785.2018.02.004 |
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| 作者姓名： | 李洪振 亓昕 高献书 秦尚彬 马茗微 张敏 王庆国 李晓颖 白赟 |
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| 作者单位： | 1. 100034 北京大学第一医院放射治疗科 |
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| 摘 要： | 目的研究中国前列腺癌患者不同治疗方式后的不良反应和生活质量的真实世界数据。 方法以北京抗癌乐园前列腺癌组患者为调查对象，通过社交媒体电子调查问卷收集患者的基本信息、诊断信息、TNM分期、治疗方式以及治疗后的不良反应，问卷设计基于欧洲癌症研究与治疗组织生命质量测定量表C30和PR25，采用Pearson χ2检验比较手术治疗患者与放射治疗组患者全身不良反应、泌尿系统不良反应、直肠不良反应、血液学不良反应、性功能障碍的发生率，概率频数小于5时采用Fisher精确检验方法。 结果共收集228例患者信息，接受过手术治疗、放射治疗（包括术后放射治疗）、内分泌治疗、化疗、粒子植入的比例分别为50.0%（114/228）、77.6%（177/228）、80.3%（183/228）、7.89%（18/228）、3.95%（9/228），治疗不良反应前10位为乏力（42.5%，97/228）、大便次数增多（42.1%，96/228）、白细胞减低（39.5%，90/228）、尿频（31.6%，72/228）、夜尿增多（27.6%，63/228）、贫血（20.2%，46/228）、腹泻（19.7%，45/228）、尿急（19.7%，45/228）、性功能障碍（18.4%，42/228）、睡眠质量下降（18.4%，42/228）。手术患者漏尿发生率高于放射治疗患者，且差异具有统计学意义（23.7% vs 5.0%，χ2=12.200，P<0.001），性功能障碍的发生率高于放射治疗患者，但差异无统计学意义（21.1% vs 15.0%，χ2=1.140，P=0.286），放射治疗患者治疗中尿频症状和大便次数增多症状均高于手术组患者，但差异无统计学意义（32.5% vs 30.7%，χ2=0.071，P=0.791；45.0% vs 34.2%，χ2=2.310，P=0.286）。针对不良反应的治疗选择居首位的是服用中药（46.9%，107/228）。 结论不同治疗手段的不良反应和对生活质量的影响不同，应根据患者对未来生活质量的要求选择合理治疗方案。
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| 关 键 词： | 前列腺肿瘤 放射疗法 手术疗法 生活质量 |
| 收稿时间： | 2017-12-16 |
Evaluation of quality of life of patients after treatment for prostate cancer:a real world study based on network questionnaires |
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| Hongzhen Li,Xin Qi,Xianshu Gao,Shangbin Qin,Mingwei Ma,Min Zhang,Qingguo Wang,Xiaoying Li,Yun Bai. Evaluation of quality of life of patients after treatment for prostate cancer:a real world study based on network questionnaires[J]. Chinese Journal of Clinicians(Electronic Version), 2018, 12(2): 80-84. DOI: 10.3877/cma.j.issn.1674-0785.2018.02.004 |
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| Authors: | Hongzhen Li Xin Qi Xianshu Gao Shangbin Qin Mingwei Ma Min Zhang Qingguo Wang Xiaoying Li Yun Bai |
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| Affiliation: | 1. Department of Radiation Oncology, First Hospital, Peking University, Beijing 100034, China |
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| Abstract: | ObjectiveTo evaluate the real world data on toxicity and quality of life of patients after treatment for prostate cancer in China. MethodsElectronic questionnaires were issued to members of the prostate cancer patient group in Beijing through the network new media method to collect the basic information of these patients, diagnostic information, TNM stage, treatment options, and adverse reactions after therapy. The questionnaire were designed based on the EORTC C30 and PR25. Systemic reactions, urinary reactions, rectal reactions, hematology toxicity, and sexual dysfunction were analyzed using the Pearson χ2 test, and Fisher′s exact test was used when the probability frequency was less than 5. ResultsA total of 228 patients were included. The proportions of patients who underwent radical, external radiotherapy (including postoperative radiotherapy), endocrine therapy, chemotherapy, and particle implantation were 50.0% (114/228), 77.6% (177/228), 80.3% (183/228), 7.89% (18/228), and 3.95% (9/228), respectively. Top ten treatment toxicities were fatigue (42.5%, 97/228), defecation frequency (42.1%, 96/228), leukopenia (39.5%, 90/228), urinary frequency (31.6%, 72/228), increased nocturia (27.6%, 63/228), anemia (20.2%, 46/228), diarrhea (19.7%, 45/228), urinary urgency (19.7%, 45/228), sexual dysfunction (18.4%, 42/228), and sleep loss (18.4%, 42/228). The incidence of urinary incontinence (23.7% vs 5%, χ2=12.200, P=0.000) and sexual dysfunction (21.1% vs 15%, χ2=1.140, P=0.286) in patients undergoing surgery was higher than that of patients undergoing radiotherapy. The rates of urinary frequency (32.5% vs 30.7%, χ2=0.071, P=0.791) and defecation frequency (45% vs 34.2%, χ2=2.310, P=0.286) in patients undergoing radiotherapy were higher than those in patients undergoing surgery. To treat these adverse reactions, the first choice in these patients was to take traditional Chinese medicine (46.9%, 107/228). ConclusionDifferent treatment methods have different toxicities and different effects on quality of life, and reasonable treatment plan should be chosen according to patients′ demands for future quality of life. |
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| Keywords: | Prostate cancer Radiotherapy Oppenheimer′s treatment Quality of life |
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