| 双嘧达莫微乳的制备及质量评价 |
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| 引用本文： | 何博赛,聂淑芳,颜廷旭,刘强,潘卫三. 双嘧达莫微乳的制备及质量评价[J]. 中国新药杂志, 2010, 0(5) |
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| 作者姓名： | 何博赛 聂淑芳 颜廷旭 刘强 潘卫三 |
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| 作者单位： | 沈阳药科大学药学院; |
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| 摘 要： | 目的:制备双嘧达莫水包油型微乳制剂,并对其稳定性及质量进行考察。方法:通过双嘧达莫在各溶媒中的溶解度初步确定处方组成,通过绘制伪三元相图对处方进行优化,考察优化处方的黏度、电导率、折光率、Zeta电位、粒径分布等理化性质,并对其稳定性进行测试。结果:在Km=3∶1时,伪三元相图形成的微乳区域最大,微乳平均粒径为59.7 nm,在高速离心、高温、强光下无分层,也无絮凝或药物析出。结论:双嘧达莫微乳制剂增加了药物的溶解度,制剂稳定,含量测定方法可靠,重复性好。
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| 关 键 词： | 双嘧达莫 微乳 伪三元相图 溶解度 质量评价 |
Preparation of dipyridamole microemulsion and its quality evaluation |
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| HE Bo-sai,NIE Shu-fang,YAN Ting-xu,LIU Qiang,PAN Wei-san. Preparation of dipyridamole microemulsion and its quality evaluation[J]. Chinese Journal of New Drugs, 2010, 0(5) |
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| Authors: | HE Bo-sai NIE Shu-fang YAN Ting-xu LIU Qiang PAN Wei-san |
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| Affiliation: | HE Bo-sai,NIE Shu-fang,YAN Ting-xu,LIU Qiang,PAN Wei-san(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Objective:To prepare the O/W microemulsion of dipyridamole and study its stability and quality.Methods:The primary compositions of microemulsion were obtained through the solubility of dipyridamole in various solvents.The formulation was optimized in pseudo-ternary phase diagrams and the physicochemical properties,including viscosity,conductivity,refractive index,zeta potential,particle size distribution and stability,were examined respectively.Results:The maximum area of microemulsion in pseudo-ternary pha... |
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| Keywords: | dipyridamole microemulsion pseudo-ternary phase diagrams solubility quality evaluation |
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