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儿童局灶性颞叶癫痫:3.0T 1H-MRS及MR海马容积分析
引用本文:孙鹤,刘兆玉,王丰哲,王晓煜,郭启勇. 儿童局灶性颞叶癫痫:3.0T 1H-MRS及MR海马容积分析[J]. 中国临床医学影像杂志, 2010, 21(1): 5-8
作者姓名:孙鹤  刘兆玉  王丰哲  王晓煜  郭启勇
作者单位:中国医科大学附属盛京医院放射科,辽宁,沈阳,110004
摘    要:目的:探讨3.0T氢质子磁共振波谱(1H-MRS)与磁共振容积测量(vMR)对儿童局灶性颞叶癫痫(fTLE)的诊断价值及临床相关因素分析。材料与方法:对30例经24小时动态脑电图确诊的fTLE患儿(年龄5~14岁,平均8.5岁)行3.0T 1H-MRS分析及vMR测量,并以随机的30名儿童(年龄5~14岁,平均8.8岁)对照,计算患者组双侧海马区代谢产物氮-乙酰天门冬氨酸(NAA)/肌酸(Cr)及海马容积、对照组任一侧海马NAA/Cr及容积,比较患儿病灶侧与病灶对侧、病灶侧与对照组、病灶对侧与对照组之间有否差异。分析癫痫发作频率等临床相关因素与海马萎缩的相关性。结果:患儿病灶侧海马区NAA/Cr(1.47±0.24)较病灶对侧(1.79±0.35)及对照组(1.81±0.27)明显减低,而病灶对侧NAA/Cr与对照组差异不明显;患儿病灶侧海马容积(2.75±0.35)较病灶对侧(3.06±0.46)和对照组(3.11±0.17)亦明显减小(对照组NAA/Cr值及海马容积参考值范围为标准)。此外,fTLE患儿癫痫发作频率与病灶侧海马容积缩小不具有相关性,而热惊厥史对海马体积具有显著影响。结论:3.0T 1H-MRS及vMR测量对儿童局灶性颞叶癫痫病灶具有定位作用,并且能够定量反映患儿海马代谢性异常及形态学改变,是为临床诊治提供可靠依据的无创性检查手段。

关 键 词:癫痫  颞叶;磁共振波谱学;海马
收稿时间:2008-12-28
修稿时间:2009-07-25

3.0T 1H-MRS and MRI volumetry analysis in the hippocampus of children with focal temporal lobe epilepsy
SUN He,LIU Zhao-yu,WANG Feng-zhe,WANG Xiao-yu,GUO Qi-yong. 3.0T 1H-MRS and MRI volumetry analysis in the hippocampus of children with focal temporal lobe epilepsy[J]. Journal of China Clinic Medical Imaging, 2010, 21(1): 5-8
Authors:SUN He  LIU Zhao-yu  WANG Feng-zhe  WANG Xiao-yu  GUO Qi-yong
Affiliation:Department of Radiology/a>;Shengjing Hospital of China Medical University/a>;Shenyang 110004/a>;China
Abstract:Objective:To study the diagnostic value of quantitative proton magnetic resonance spectroscopy(1H-MRS) and volumetric MR(vMR) in the hippocampus of children on focal temporal lobe epilepsy(fTLE),and analyse the relationship between the volume change of the hippocampus and clinical factors.Methods:3.0T 1H-MRS and vMRI were used to study 30 children(mean age 8.5 years,age 5 to 14 years) with unilateral fTLE,proven by 24 hours active electroencephalogram,and 30 random healthy children(mean age 8.8 years,age 5 ...
Keywords:Epilepsy  temporal lobe  Hippocampus  Magnetic resonance spectroscopy  
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