| MUC15和PI3K/Akt 表达与胃癌临床病理特征及预后的相关性研究 |
| |
| 引用本文： | 韩志伟,戎瑞洲,孔鹏洲,程彩霞,张燕燕,董金垚,李曙晶,郭建昇. MUC15和PI3K/Akt 表达与胃癌临床病理特征及预后的相关性研究[J]. 中国肿瘤临床, 2016, 43(2): 56-61. DOI: 10.3969/j.issn.1000-8179.2016.02.211 |
| |
| 作者姓名： | 韩志伟 戎瑞洲 孔鹏洲 程彩霞 张燕燕 董金垚 李曙晶 郭建昇 |
| |
| 作者单位： | 作者单位:①山西医科大学第一医院普通外科(太原市 030001);②山西医科大学转化医学研究中心;③山西医科大学细胞生理学教育部重点实验室;④山西医科大学第一医院病理科 |
| |
| 摘 要： | 目的:探讨MUC15 和PI 3K/Akt的表达与胃癌临床病理特征和预后的关系。方法:采用组织芯片和免疫组织化学法检测144 例胃癌组织及对应癌旁组织中MUC15、Akt的表达。结果:MUC15在胃癌中阳性表达率为79.8% ，高于癌旁组织中的阳性表达率22.2%（P < 0.01）；Akt在胃癌中阳性表达率为80.6% ，高于癌旁组织的阳性表达率16.7%（P < 0.01）。 MUC15和Akt表达均与胃癌分化程度、浸润深度、有无淋巴结转移和TNM 分期相关（P < 0.05）；且胃癌组织中MUC15表达和Akt表达呈正相关（P = 0.001）。 单因素生存分析显示，MUC15和Akt高表达均与生存时间呈负相关（P < 0.05）。 Cox 多元回归分析提示，MUC15和Akt同时阳性的胃癌患者预后更差（HR= 3.115，P < 0.05）。 结论:MUC15可能通过PI 3K/Akt细胞信号转导通路参与胃癌的发生、发展、浸润转移，MUC15结合Akt是胃癌预后强有力的预测因子。
|
| 关 键 词： | 胃癌? 免疫组织化学 MUC15? PI 3K/Akt? 预后 |
| 收稿时间： | 2015-11-06 |
Expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clini-copathological characteristics and prognosis |
| |
| Affiliation: | 1Department of General Surgery, the First Hospital, Shanxi Medical University, Taiyuan 030001, China; |
| |
| Abstract: | Objective:To analyze the expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clinicopathologi-cal characteristics and prognosis. Methods:The expression of MUC15 and Akt was detected in 144 cases of gastric carcinoma tissues and corresponding para-carcinoma tissues by tissue microarray and immunohistochemistry. Results:The positive expression rate of MUC15 in gastric carcinoma was 79.8%, higher than that of para-carcinoma tissues (22.2%, P<0.01). The positive expression rate of Akt protein in gastric carcinoma was 80.6%, higher than that of para-carcinoma tissues (16.7%, P<0.01). The expression of MUC15 and Akt was statistically associated with the grades of differentiation, invasion depth, lymphatic metastasis, TNM stage of tumor tissues (P<0.05), and the positive correlation between the two protein expression that appear in the gastric tumor tissue (P=0.001). Univariate survival analysis showed that the over-expression of either MUC15 or Akt was inversely correlated with the survival time (P<0.05 and P<0.01, respectively). Cox multiple regression analysis indicated that patients with over-expression of both MUC15 and Akt had the worst prognoses (HR=3.115, P<0.05). Conclusion:MUC15 may be involved in the occurrence, development, invasion, and metastasis of gastric cancer through the PI3K/Akt cell signaling pathway, and the expression of MUC15 combined with Akt is a powerful predictor for the prognosis of gastric cancer. |
| |
| Keywords: | gastric carcinoma immunohistochemistry MUC15 PI3K/Akt prognosis |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载免费的PDF全文 |
|
