|
|||||
|
|
| 尿苷二磷酸葡醛酸转移酶的研究进展 | |
| 引用本文： | 崔冬雪. 尿苷二磷酸葡醛酸转移酶的研究进展[J]. 中国药理学与毒理学杂志, 2013, 27(1): 123-126. DOI: 10.3867/j.issn.1000-3002.2013.01.024 |
| 作者姓名： | 崔冬雪 |
| 作者单位： | 邢台市人民医院药剂科,河北邢台,054000 |
| 摘 要： | 尿苷二磷酸葡醛酸转移酶(UGT)是体内最重要的Ⅱ相代谢酶,它可以参与许多内源性物质如胆红素、甾体激素、甲状腺激素、胆汁酸和脂溶性维生素等的代谢,在许多药物如阿片类药物、镇痛药、非甾体抗炎药和抗惊厥药等的代谢中也发挥着重要的作用。UGT在药物的吸收、分布、代谢和排泄中发挥重要作用。研究UGT特别是其基因多态性及其介导的药物-药物相互作用不仅可以指导临床用药,也可以揭示内源性物质代谢紊乱的机制。本文就UGT的分类、组织分布、对药物吸收的影响、基因多态性及其所介导的药物-药物相互作用进行综述。 |
| 关 键 词： | 尿苷二磷酸葡醛酸 转移酶类 药物相互作用 多态性,单核苷酸 |
| 收稿时间： | 2012-05-10 |
| 修稿时间： | 2012-10-30 |
Progress of UDP-glucuronosyltransferases |
|
| CUI Dong-xue. Progress of UDP-glucuronosyltransferases[J]. Chinese Journal of Pharmacology and Toxicology, 2013, 27(1): 123-126. DOI: 10.3867/j.issn.1000-3002.2013.01.024 | |
| Authors: | CUI Dong-xue |
| Affiliation: | Pharmacy Department, People's Hospital of Xingtai City, Hebei Province, Xingtai 054000, China |
| Abstract: | UDP-glucuronosyltransferases (UGT) are the most important phaseⅡ drug metabolizing enzyme, which can metabolize not only various endogenous substances, such as bilirubin, steroid hormones, thyroid hormones, bile acids and fat-soluble vitamins, but also many drugs, such as opioids, analgesics, NSAID and anticonvulsants. UGT plays an important role in drug absorbtion, metabolism, distribution and excretion. Furthermore, the inhibition or induction of UGT could not only result in serious drug-drug interactions, but also induce metabolic disorders of endogenous substances, for which evaluation of the inhibitory or induction effects of compounds on UGT is very important in clinic. This paper reviewed UGT in terms of its classification, tissue distribution, effect on drug absorption, gene polymorphism and related drug-drug interactions. |
| Keywords: | uridine diphosphate glucuronic acid transferases drug interactions polymorphism single nucleotide |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国药理学与毒理学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国药理学与毒理学杂志》下载全文 | |