Pattern of distribution of syngeneic spleen cells in the lymphoid organs of neonatally thymectomized mice |
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| Authors: | A. Ka&#x telan, B. Naki&#x , O. Springer, J. Miku&#x ka, D. Volf |
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| Affiliation: | A. Kaštelan, B. Nakić, O. Springer, J. Mikuška, and D. Volf |
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| Abstract: | Newborn mice were thymectomized and intraperitoneally inoculated with syngeneic spleen cells on days 0, 3, 7 and 20 after birth. Donor cells were chromosomally distinguishable from host cells (T6). Cytological analysis performed between days 2 and 118 post-natal revealed greatly increased proportions of donor cells in host lymph nodes if comparison were made with similarly injected non-thymectomized hosts. The effect is highly specific, since the proportions of donor cells in the host spleen and bone marrow remained similar to those in control, non-thymectomized mice (syngeneic standard). The mechanism behind this phenomenon is unclear. |
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