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Influence of cholecystectomy on sphincter of Oddi motility |
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| Authors: | W Luman A Williams A Pryde G Smith S Nixon R Heading K Palmer |
| Affiliation: | Gastrointestinal Unit, Western General Hospital, Edinburgh, Scotland, UK. |
| Abstract: | Background—Gall bladder and sphincter of Oddi (SO)function are coordinated by hormonal and neuronal mechanisms. Nervefibres pass between the gall bladder and the SO via the cystic duct. Itis therefore possible that cholecystectomy may alter SO motility. Aim—To investigate the effect of cholecystectomyon SO function Methods—SO manometry was performed in five women(median age 52 years), a few days before and six months afterlaparoscopic cholecystectomy which was undertaken for uncomplicatedcholelithiasis. Basal and post-cholecystokinin (CCK) SO motility were measured. Results—All patients were symptom free afterlaparoscopic cholecystectomy. Prior to surgery common bile ductpressure, and tonic and phasic SO motility were normal and phasiccontractions were inhibited by intravenous CCK (1 Ivy Dog Unit/kg). Sixmonths later, common bile duct pressure and baseline tonic and phasic activity were unchanged but CCK failed to suppress phasic activity. Conclusion—Cholecystectomy, at least in the shortterm, suppresses the normal inhibitory effect of pharmacological dosesof CCK on the SO. The mechanism of this effect is unknown but it couldbe due to SO denervation. Keywords:sphincter of Oddi; cholecystectomy; cholecystokinin |
| Keywords: | sphincter of Oddi cholecystectomy cholecystokinin |